Co-crystallisation at high pressure - an additional tool for the preparation and study of co-crystals

Iain D. H. Oswald; Colin R. Pulham

doi:10.1039/b805591b

Co-crystallisation at high pressure - an additional tool for the preparation and study of co-crystals

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Abstract / Description of output

Crystallisation of paracetamol and piperazine from ethanol at a pressure of 0.57 GPa produced an ethanol solvate of a 2 : 1 co-crystal of paracetamol : piperazine. This contrasts with crystallisation from ethanol at ambient pressure for which only an unsolvated 2 : 1 co-crystal of paracetamol : piperazine has been obtained. The hydrogen bonding arrangements of the two compounds are very different and a striking feature of the solvate is the presence of an unusually short hydrogen bond between the phenolic and amine groups.

Original language	English
Pages (from-to)	1114-1116
Number of pages	3
Journal	CrystEngComm
Volume	10
Issue number	9
DOIs	https://doi.org/10.1039/b805591b
Publication status	Published - 2008

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abstract = "Crystallisation of paracetamol and piperazine from ethanol at a pressure of 0.57 GPa produced an ethanol solvate of a 2 : 1 co-crystal of paracetamol : piperazine. This contrasts with crystallisation from ethanol at ambient pressure for which only an unsolvated 2 : 1 co-crystal of paracetamol : piperazine has been obtained. The hydrogen bonding arrangements of the two compounds are very different and a striking feature of the solvate is the presence of an unusually short hydrogen bond between the phenolic and amine groups.",

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AB - Crystallisation of paracetamol and piperazine from ethanol at a pressure of 0.57 GPa produced an ethanol solvate of a 2 : 1 co-crystal of paracetamol : piperazine. This contrasts with crystallisation from ethanol at ambient pressure for which only an unsolvated 2 : 1 co-crystal of paracetamol : piperazine has been obtained. The hydrogen bonding arrangements of the two compounds are very different and a striking feature of the solvate is the presence of an unusually short hydrogen bond between the phenolic and amine groups.

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JO - CrystEngComm

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Co-crystallisation at high pressure - an additional tool for the preparation and study of co-crystals

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