Cobalt-catalyzed reductive Mannich reactions of 4-acryloylmorpholine with N-tosyl aldimines

Oscar Prieto, Hon Wai Lam

Research output: Contribution to journalArticlepeer-review

Abstract

Using cobalt catalysis, diethylzinc promotes the conjugate reduction of 4-acryloylmorpholine to produce the corresponding ethylzinc enolate, which reacts with N-tosyl aldimines to afford beta-aminoamides.

Original languageEnglish
Pages (from-to)55-57
Number of pages3
JournalOrganic & Biomolecular chemistry
Volume6
Issue number1
DOIs
Publication statusPublished - 2008

Keywords

  • BETA-AMINO ACIDS
  • STEREOSELECTIVE SYNTHESIS
  • ASYMMETRIC-SYNTHESIS
  • CINCHONA ALKALOIDS
  • ALDOL REACTIONS
  • ANTI-MANNICH
  • KETO-ESTERS
  • IMINES
  • ALDEHYDES
  • LACTAMS

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