Coeliac screening in a Scottish cohort of children with type 1 diabetes mellitus: is DQ typing the way forward?

R T Mitchell, A Sun, A Mayo, M Forgan, A Comrie, P M Gillett

Research output: Contribution to journalArticlepeer-review

Abstract

Background Children with type 1 diabetes mellitus (T1DM) are at increased risk of coeliac disease (CD). Recent guidelines indicate coeliac screening should include HLA typing for CD predisposing (DQ2/DQ8) alleles and those negative for these alleles require no further coeliac screening.

Methods Children (n=176) with T1DM attending clinics across two Scottish regions were screened for HLA DQ2/DQ8 as part of routine screening. Data collected included the frequency of DQ2/DQ8 genotypes and the additional cost of HLA screening.

Results Overall, DQ2/DQ8 alleles were identified in 94% of patients. The additional cost of HLA typing was £3699.52 (£21.02 per patient). All patients with known CD (11/176) were positive for DQ2/DQ8 and all were diagnosed with CD within 5 years of T1DM diagnosis.

Conclusions The vast majority of children with T1DM have CD-predisposing HLA genotypes limiting the number of patients that can be excluded from further screening. We conclude that HLA genotyping is not currently indicated for CD screening in this population.
Original languageEnglish
JournalArchives of Disease in Childhood
Early online date31 Dec 2015
DOIs
Publication statusE-pub ahead of print - 31 Dec 2015

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