Cognition and amyloid load in Alzheimer disease imaged with florbetapir F 18 (AV-45) positron emission tomography

Paul B. Rosenberg*, D. F. Wong, S. L. Edell, J. S. Ross, A. D. Joshi, J. R. Brašić, Y. Zhou, V. Raymont, A. Kumar, H. T. Ravert, R. F. Dannals, M. J. Pontecorvo, D. M. Skovronsky, C. G. Lyketsos

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: To examine the association between regional brain uptake of a novel amyloid positron emission tomography (PET) tracer florbetapir F 18 ([ 18F]-AV-45) and cognitive performance in a pilot study. Design: Cross-sectional comparison of [18F]-AV- 45 in AD patients versus controls. Setting: Three specialty memory clinics. Participants: Eleven participants with probable Alzheimer disease (AD) by NINDS/ADRDA criteria and 15 healthy comparison (HC) participants. Measurements: Participants underwent PET imaging following a 370 MBq (10 mCi) intravenous administration of [ 18F]-AV-45. Regional/cerebellar standardized uptake value ratios (SUVRs) were calculated. Cognition was assessed using Mini-Mental State Examination, Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog), Wechsler Logical Memory IA (immediate recall) test (LMIA), and verbal category fluency. Results: Greater [18F]-AV-45 SUVR was associated with poorer performance on all cognitive tests. In the HC group, occipital, parietal, precuneus, temporal, and cortical average SUVR was associated with greater ADAS-Cog, and greater anterior cingulate SUVR was associated with lower LMIA. Two HC participants had [18F]-AV-45 cortical/cerebellar SUVR greater than 1.5, one of whom had deficits in episodic recall and on follow-up met criteria for amnestic mild cognitive impairment. Conclusion: [ 18F]-AV-45 SUVR in several brain regions was associated with worse global cognitive performance particularly in HC, suggesting its potential as a marker of preclinical AD.

Original languageEnglish
Pages (from-to)272-278
Number of pages7
JournalAmerican Journal of Geriatric Psychiatry
Issue number3
Publication statusPublished - Mar 2013


  • 18-flourine
  • Alzheimer
  • Amyloid
  • Cognition
  • PET tracer
  • Positron emission tomography
  • Standardized uptake value ratios


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