Cognitive decline and quality of life in incident Parkinson's disease: The role of attention

ICICLE-PD study group; Rachael A Lawson; Alison J Yarnall; Gordon W Duncan; David P Breen; Tien K Khoo; Caroline H Williams-Gray; Roger A Barker; Daniel Collerton; John-Paul Taylor; David J Burn

doi:10.1016/j.parkreldis.2016.04.009

Cognitive decline and quality of life in incident Parkinson's disease: The role of attention

ICICLE-PD study group, Rachael A Lawson, Alison J Yarnall, Gordon W Duncan, David P Breen, Tien K Khoo, Caroline H Williams-Gray, Roger A Barker, Daniel Collerton, John-Paul Taylor, David J Burn

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

INTRODUCTION: Parkinson's disease dementia (PDD) is associated with poorer quality of life (QoL). Prior to the onset of PDD, many patients experience progressive cognitive impairment. There is a paucity of longitudinal studies investigating the effects of cognitive decline on QoL. This study aimed to determine the longitudinal impact of cognitive change on QoL in an incident PD cohort.

METHODS: Recently diagnosed patients with PD (n = 212) completed a schedule of neuropsychological assessments and QoL measures; these were repeated after 18 (n = 190) and 36 months (n = 158). Mild cognitive impairment (PD-MCI) was classified with reference to the Movement Disorder Society criteria. Principal component analysis was used to reduce 10 neuropsychological tests to three cognitive factors: attention, memory/executive function, and global cognition.

RESULTS: Baseline PD-MCI was a significant contributor to QoL (β = 0.2, p < 0.01). For those subjects (9%) who developed dementia, cognitive function had a much greater impact on QoL (β = 10.3, p < 0.05). Multivariate modelling showed attentional deficits had the strongest predictive power (β = -2.3, p < 0.01); brief global tests only modestly predicted decline in QoL (β = -0.4, p < 0.01).

CONCLUSIONS: PD-MCI was associated with poorer QoL over three years follow up. Cognitive impairment had a greater impact on QoL in individuals who developed dementia over follow-up. Impaired attention was a significant determinant of QoL in PD. Interventions which improve concentration and attention in those with PD could potentially improve QoL.

Original language	English
Pages (from-to)	47-53
Number of pages	7
Journal	Parkinsonism & Related Disorders
Volume	27
Early online date	11 Apr 2016
DOIs	https://doi.org/10.1016/j.parkreldis.2016.04.009
Publication status	Published - Jun 2016

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10.1016/j.parkreldis.2016.04.009

Duncan G Cognitive decline
2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Final published version, 477 KBLicence: Creative Commons: Attribution (CC-BY)

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ICICLE-PD study group, Lawson, R. A., Yarnall, A. J., Duncan, G. W., Breen, D. P., Khoo, T. K., Williams-Gray, C. H., Barker, R. A., Collerton, D., Taylor, J.-P., & Burn, D. J. (2016). Cognitive decline and quality of life in incident Parkinson's disease: The role of attention. Parkinsonism & Related Disorders, 27, 47-53. https://doi.org/10.1016/j.parkreldis.2016.04.009

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title = "Cognitive decline and quality of life in incident Parkinson's disease: The role of attention",

abstract = "INTRODUCTION: Parkinson's disease dementia (PDD) is associated with poorer quality of life (QoL). Prior to the onset of PDD, many patients experience progressive cognitive impairment. There is a paucity of longitudinal studies investigating the effects of cognitive decline on QoL. This study aimed to determine the longitudinal impact of cognitive change on QoL in an incident PD cohort.METHODS: Recently diagnosed patients with PD (n = 212) completed a schedule of neuropsychological assessments and QoL measures; these were repeated after 18 (n = 190) and 36 months (n = 158). Mild cognitive impairment (PD-MCI) was classified with reference to the Movement Disorder Society criteria. Principal component analysis was used to reduce 10 neuropsychological tests to three cognitive factors: attention, memory/executive function, and global cognition.RESULTS: Baseline PD-MCI was a significant contributor to QoL (β = 0.2, p < 0.01). For those subjects (9%) who developed dementia, cognitive function had a much greater impact on QoL (β = 10.3, p < 0.05). Multivariate modelling showed attentional deficits had the strongest predictive power (β = -2.3, p < 0.01); brief global tests only modestly predicted decline in QoL (β = -0.4, p < 0.01).CONCLUSIONS: PD-MCI was associated with poorer QoL over three years follow up. Cognitive impairment had a greater impact on QoL in individuals who developed dementia over follow-up. Impaired attention was a significant determinant of QoL in PD. Interventions which improve concentration and attention in those with PD could potentially improve QoL.",

author = "{ICICLE-PD study group} and Lawson, {Rachael A} and Yarnall, {Alison J} and Duncan, {Gordon W} and Breen, {David P} and Khoo, {Tien K} and Williams-Gray, {Caroline H} and Barker, {Roger A} and Daniel Collerton and John-Paul Taylor and Burn, {David J}",

year = "2016",

month = jun,

doi = "10.1016/j.parkreldis.2016.04.009",

language = "English",

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T1 - Cognitive decline and quality of life in incident Parkinson's disease

T2 - The role of attention

AU - ICICLE-PD study group

AU - Lawson, Rachael A

AU - Yarnall, Alison J

AU - Duncan, Gordon W

AU - Breen, David P

AU - Khoo, Tien K

AU - Williams-Gray, Caroline H

AU - Barker, Roger A

AU - Collerton, Daniel

AU - Taylor, John-Paul

AU - Burn, David J

PY - 2016/6

Y1 - 2016/6

N2 - INTRODUCTION: Parkinson's disease dementia (PDD) is associated with poorer quality of life (QoL). Prior to the onset of PDD, many patients experience progressive cognitive impairment. There is a paucity of longitudinal studies investigating the effects of cognitive decline on QoL. This study aimed to determine the longitudinal impact of cognitive change on QoL in an incident PD cohort.METHODS: Recently diagnosed patients with PD (n = 212) completed a schedule of neuropsychological assessments and QoL measures; these were repeated after 18 (n = 190) and 36 months (n = 158). Mild cognitive impairment (PD-MCI) was classified with reference to the Movement Disorder Society criteria. Principal component analysis was used to reduce 10 neuropsychological tests to three cognitive factors: attention, memory/executive function, and global cognition.RESULTS: Baseline PD-MCI was a significant contributor to QoL (β = 0.2, p < 0.01). For those subjects (9%) who developed dementia, cognitive function had a much greater impact on QoL (β = 10.3, p < 0.05). Multivariate modelling showed attentional deficits had the strongest predictive power (β = -2.3, p < 0.01); brief global tests only modestly predicted decline in QoL (β = -0.4, p < 0.01).CONCLUSIONS: PD-MCI was associated with poorer QoL over three years follow up. Cognitive impairment had a greater impact on QoL in individuals who developed dementia over follow-up. Impaired attention was a significant determinant of QoL in PD. Interventions which improve concentration and attention in those with PD could potentially improve QoL.

AB - INTRODUCTION: Parkinson's disease dementia (PDD) is associated with poorer quality of life (QoL). Prior to the onset of PDD, many patients experience progressive cognitive impairment. There is a paucity of longitudinal studies investigating the effects of cognitive decline on QoL. This study aimed to determine the longitudinal impact of cognitive change on QoL in an incident PD cohort.METHODS: Recently diagnosed patients with PD (n = 212) completed a schedule of neuropsychological assessments and QoL measures; these were repeated after 18 (n = 190) and 36 months (n = 158). Mild cognitive impairment (PD-MCI) was classified with reference to the Movement Disorder Society criteria. Principal component analysis was used to reduce 10 neuropsychological tests to three cognitive factors: attention, memory/executive function, and global cognition.RESULTS: Baseline PD-MCI was a significant contributor to QoL (β = 0.2, p < 0.01). For those subjects (9%) who developed dementia, cognitive function had a much greater impact on QoL (β = 10.3, p < 0.05). Multivariate modelling showed attentional deficits had the strongest predictive power (β = -2.3, p < 0.01); brief global tests only modestly predicted decline in QoL (β = -0.4, p < 0.01).CONCLUSIONS: PD-MCI was associated with poorer QoL over three years follow up. Cognitive impairment had a greater impact on QoL in individuals who developed dementia over follow-up. Impaired attention was a significant determinant of QoL in PD. Interventions which improve concentration and attention in those with PD could potentially improve QoL.

U2 - 10.1016/j.parkreldis.2016.04.009

DO - 10.1016/j.parkreldis.2016.04.009

M3 - Article

C2 - 27094482

SN - 1353-8020

VL - 27

SP - 47

EP - 53

JO - Parkinsonism & Related Disorders

JF - Parkinsonism & Related Disorders

ER -

Cognitive decline and quality of life in incident Parkinson's disease: The role of attention

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