Cognitive estimation: Performance of patients with focal frontal and posterior lesions

Lisa Cipolotti, Sarah E. MacPherson, Sara Gharooni, Natasja van-Harskamp, Tim Shallice, Edgar Chan, Parashkev Nachev

Research output: Contribution to journalArticlepeer-review

Abstract

The Cognitive Estimation Test (CET) is a widely used test to investigate estimation abilities requiring complex processes such as reasoning, the development and application of appropriate strategies,response plausibility checking as well as general knowledge and numeracy(e.g., Shallice and Evans, 1978; MacPherson et al, 2014). Thus far, it remains unknown whether the CET is both sensitive and specific to frontal lobe dysfunction. Neuroimaging techniques may not represent a useful methodology for answering this question since the complex processes involved are likely to be associated with a large network of brain regions, some of which are not functionally necessary to successfully carry out the CET. Instead, neuropsychological studies may represent a more promising investigation tool for identifying the brain areas necessary for CET performance. We recently developed two new versions of the CET (CET-A and CET-B; MacPherson et al, 2014). We investigated the overall performance and conducted an error analysis on CET-A in patients with focal, unilateral, frontal (n= 38) or posterior (n= 22) lesions and healthy controls (n=39). We found that frontal patients' performance was impaired compared to healthy controls on CET demonstrating that our CET-Ais affected by frontal lobe damage. We also found that frontal patients generated significantly poorer estimates than posterior patients on CETA. This could not be explained by impairments in fluid intelligence. The error analyses suggested that for CET-A, extreme and very extreme responses are impaired following frontal lobe damage. However, only very extreme responses are significantly more impaired following frontal lobe than posterior damage and so represent a measure restricted to frontal"executive" impairment, in addition to overall CET performance.
Original languageEnglish
JournalNeuropsychologia
Early online date13 Aug 2017
DOIs
Publication statusE-pub ahead of print - 13 Aug 2017

Keywords

  • Cognitive Estimation Test
  • prefrontal cortex
  • executive functions
  • fluid Intelligence

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