Cognitive Function in People With Familial Risk of Depression

Breda Cullen; Marc J Gameroff; Joey Ward; Mark E S Bailey; Donald M Lyall; Laura M Lyall; Niamh MacSweeney; Eleanor Murphy; Natasha Sangha; Xueyi Shen; Rona J. Strawbridge; Milenna Van Dijk; Xingxing Zhu; Daniel Smith; Ardesheer Talati; Heather Whalley; Jonathan Cavanagh; Myrna M Weissman

doi:10.1001/jamapsychiatry.2023.0716

Cognitive Function in People With Familial Risk of Depression

Breda Cullen^*, Marc J Gameroff, Joey Ward, Mark E S Bailey, Donald M Lyall, Laura M Lyall, Niamh MacSweeney, Eleanor Murphy, Natasha Sangha, Xueyi Shen, Rona J. Strawbridge, Milenna Van Dijk, Xingxing Zhu, Daniel Smith, Ardesheer Talati, Heather Whalley, Jonathan Cavanagh, Myrna M Weissman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	JAMA Psychiatry
DOIs	https://doi.org/10.1001/jamapsychiatry.2023.0716
Publication status	Published - 19 Apr 2023

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10.1001/jamapsychiatry.2023.0716

Cullen et al, JAMA Psychiatry, in press.Accepted author manuscript, 310 KBLicence: Creative Commons: Attribution (CC-BY)

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Cullen, B., Gameroff, M. J., Ward, J., Bailey, M. E. S., Lyall, D. M., Lyall, L. M., MacSweeney, N., Murphy, E., Sangha, N., Shen, X., Strawbridge, R. J., Van Dijk, M., Zhu, X., Smith, D., Talati, A., Whalley, H., Cavanagh, J., & Weissman, M. M. (2023). Cognitive Function in People With Familial Risk of Depression. JAMA Psychiatry. https://doi.org/10.1001/jamapsychiatry.2023.0716

@article{319418ebd5c14fa8821ab60cbe635f33,

title = "Cognitive Function in People With Familial Risk of Depression",

author = "Breda Cullen and Gameroff, {Marc J} and Joey Ward and Bailey, {Mark E S} and Lyall, {Donald M} and Lyall, {Laura M} and Niamh MacSweeney and Eleanor Murphy and Natasha Sangha and Xueyi Shen and Strawbridge, {Rona J.} and {Van Dijk}, Milenna and Xingxing Zhu and Daniel Smith and Ardesheer Talati and Heather Whalley and Jonathan Cavanagh and Weissman, {Myrna M}",

note = "Funding Information: Conflict of Interest Disclosures: Dr Cullen has received grants from the Scottish Executive Chief Scientist Office during the conduct of the study. Dr Weissman has received grants from the National Institute of Mental Health during the conduct of the study; grants from John Templeton Foundation, National Institute of Mental Health, and Brain and Behavior Foundation; and royalties from Oxford Press, APA Publishing, Perseus Press, and Multihealth Systems outside the submitted work. No other disclosures were reported. Funding Information: Funding/Support: This work was supported in part by grant DTF/14/03 from the Scottish Executive Chief Scientist Office (Dr Cullen) and grant R01MH036197 from the National Institute of Mental Health (Dr Weissman). Dr L. Lyall is supported by a JMAS Sim Fellowship from the Royal College of Physicians of Edinburgh and a Lord Kelvin Adam Smith Fellowship from the University of Glasgow . Ms MacSweeney is supported by a Mental Health Research UK PhD Studentship. Dr Strawbridge is supported by a UK Research and Innovation Health Data Research-UK Fellowship MR/S003061/1 and a Lord Kelvin Adam Smith Fellowship from the University of Glasgow . Dr van Dijk is funded by National Institute of Mental Health grant K99MH129611 and American Foundation for Suicide Prevention Young Investigator Award YIG-R-001-19. Funding Information: Additional Information: Data used in the preparation of this article were obtained from the Adolescent Brain Cognitive Development (ABCD) study, held in the National Institute of Mental Health data archive. This is a multisite, longitudinal study designed to recruit more than 10 000 children aged 9 to 10 years and observe them over 10 years into early adulthood. The ABCD study is supported by the National Institutes of Health and additional federal partners under award numbers U01DA041048, U01DA050989, U01DA051016, U01DA041022, U01DA051018, U01DA051037, U01DA050987, U01DA041174, U01DA041106, U01DA041117, U01DA041028, U01DA041134, U01DA050988, U01DA051039, U01DA041156, U01DA041025, U01DA041120, U01DA051038, U01DA041148, U01DA041093, U01DA041089, U24DA041123, and U24DA041147. A full list of supporters is available at https://abcdstudy.org/federal-partners.html . A listing of participating sites and a complete listing of the study investigators can be found at https://abcdstudy.org/consortium_members/ . ABCD Consortium Investigators designed and implemented the study and/or provided data but did not necessarily participate in the analysis or writing of this report. This manuscript reflects the views of the authors and may not reflect the opinions or views of the National Institutes of Health or ABCD Consortium Investigators. The ABCD data repository grows and changes over time. The ABCD data used in this report came from Annual Release 4.0 (study number 1299). The National Longitudinal Study of Adolescent to Adult Health (Add Health) is directed by Robert A. Hummer and funded by the National Institute on Aging cooperative agreements U01 AG071448 (Hummer) and U01 AG071450 (Aiello and Hummer) at the University of North Carolina at Chapel Hill. Waves I to V data are from the Add Health Program Project, grant P01 HD31921 (Harris) from Eunice Kennedy Shriver National Institute of Child Health and Human Development, with cooperative funding from 23 other federal agencies and foundations. Add Health was designed by J. Richard Udry, Peter S. Bearman, and Kathleen Mullan Harris at the University of North Carolina at Chapel Hill. This research has been conducted using the UK Biobank Resource under Application Number 11332 (Dr Cullen). UK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government, and the Northwest Regional Development Agency. It has also had funding from the Welsh Government, British Heart Foundation, Cancer Research UK, and Diabetes UK. Publisher Copyright: {\textcopyright} 2023 American Medical Association. All rights reserved.",

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doi = "10.1001/jamapsychiatry.2023.0716",

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T1 - Cognitive Function in People With Familial Risk of Depression

AU - Cullen, Breda

AU - Gameroff, Marc J

AU - Ward, Joey

AU - Bailey, Mark E S

AU - Lyall, Donald M

AU - Lyall, Laura M

AU - MacSweeney, Niamh

AU - Murphy, Eleanor

AU - Sangha, Natasha

AU - Shen, Xueyi

AU - Strawbridge, Rona J.

AU - Van Dijk, Milenna

AU - Zhu, Xingxing

AU - Smith, Daniel

AU - Talati, Ardesheer

AU - Whalley, Heather

AU - Cavanagh, Jonathan

AU - Weissman, Myrna M

N1 - Funding Information: Conflict of Interest Disclosures: Dr Cullen has received grants from the Scottish Executive Chief Scientist Office during the conduct of the study. Dr Weissman has received grants from the National Institute of Mental Health during the conduct of the study; grants from John Templeton Foundation, National Institute of Mental Health, and Brain and Behavior Foundation; and royalties from Oxford Press, APA Publishing, Perseus Press, and Multihealth Systems outside the submitted work. No other disclosures were reported. Funding Information: Funding/Support: This work was supported in part by grant DTF/14/03 from the Scottish Executive Chief Scientist Office (Dr Cullen) and grant R01MH036197 from the National Institute of Mental Health (Dr Weissman). Dr L. Lyall is supported by a JMAS Sim Fellowship from the Royal College of Physicians of Edinburgh and a Lord Kelvin Adam Smith Fellowship from the University of Glasgow . Ms MacSweeney is supported by a Mental Health Research UK PhD Studentship. Dr Strawbridge is supported by a UK Research and Innovation Health Data Research-UK Fellowship MR/S003061/1 and a Lord Kelvin Adam Smith Fellowship from the University of Glasgow . Dr van Dijk is funded by National Institute of Mental Health grant K99MH129611 and American Foundation for Suicide Prevention Young Investigator Award YIG-R-001-19. Funding Information: Additional Information: Data used in the preparation of this article were obtained from the Adolescent Brain Cognitive Development (ABCD) study, held in the National Institute of Mental Health data archive. This is a multisite, longitudinal study designed to recruit more than 10 000 children aged 9 to 10 years and observe them over 10 years into early adulthood. The ABCD study is supported by the National Institutes of Health and additional federal partners under award numbers U01DA041048, U01DA050989, U01DA051016, U01DA041022, U01DA051018, U01DA051037, U01DA050987, U01DA041174, U01DA041106, U01DA041117, U01DA041028, U01DA041134, U01DA050988, U01DA051039, U01DA041156, U01DA041025, U01DA041120, U01DA051038, U01DA041148, U01DA041093, U01DA041089, U24DA041123, and U24DA041147. A full list of supporters is available at https://abcdstudy.org/federal-partners.html . A listing of participating sites and a complete listing of the study investigators can be found at https://abcdstudy.org/consortium_members/ . ABCD Consortium Investigators designed and implemented the study and/or provided data but did not necessarily participate in the analysis or writing of this report. This manuscript reflects the views of the authors and may not reflect the opinions or views of the National Institutes of Health or ABCD Consortium Investigators. The ABCD data repository grows and changes over time. The ABCD data used in this report came from Annual Release 4.0 (study number 1299). The National Longitudinal Study of Adolescent to Adult Health (Add Health) is directed by Robert A. Hummer and funded by the National Institute on Aging cooperative agreements U01 AG071448 (Hummer) and U01 AG071450 (Aiello and Hummer) at the University of North Carolina at Chapel Hill. Waves I to V data are from the Add Health Program Project, grant P01 HD31921 (Harris) from Eunice Kennedy Shriver National Institute of Child Health and Human Development, with cooperative funding from 23 other federal agencies and foundations. Add Health was designed by J. Richard Udry, Peter S. Bearman, and Kathleen Mullan Harris at the University of North Carolina at Chapel Hill. This research has been conducted using the UK Biobank Resource under Application Number 11332 (Dr Cullen). UK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government, and the Northwest Regional Development Agency. It has also had funding from the Welsh Government, British Heart Foundation, Cancer Research UK, and Diabetes UK. Publisher Copyright: © 2023 American Medical Association. All rights reserved.

PY - 2023/4/19

Y1 - 2023/4/19

U2 - 10.1001/jamapsychiatry.2023.0716

DO - 10.1001/jamapsychiatry.2023.0716

M3 - Article

SN - 2168-622X

JO - JAMA Psychiatry

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