Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis

Olivia Hamilton, Ellen Backhouse, Esther Janssen, Angela Jochems, Caragh Maher, Tuula Ritakari, Anna Stevenson, Lihua Xia, Ian Deary, Joanna Wardlaw

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

This paper is a proposal for an update on the characterisation of cognitive impairments associated with sporadic cerebral small vessel disease (SVD). We pose a series of questions about the nature of SVD-related cognitive impairments and provide answers based on a comprehensive review and meta-analysis of published data from 69 studies. Although SVD is thought primarily to affect executive function and processing speed, we hypothesise that SVD affects all major domains of cognitive ability. We also identify low levels of education as a potentially modifiable risk factor for SVD-related cognitive impairment. Therefore, we propose the use of comprehensive cognitive assessments and the measurement of educational level both in clinics and research settings, and suggest several recommendations for future research.
Original languageEnglish
JournalAlzheimer's & Dementia: The Journal of the Alzheimer's Association
Publication statusPublished - 13 Nov 2020

Keywords / Materials (for Non-textual outputs)

  • cerebral small vessel disease
  • vascular cognitive impairment
  • cognitive ability
  • lacunar stroke
  • vascular dementia
  • systematic review
  • meta-analysis


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