Cognitive outcome after on- and off-pump coronary artery bypass grafting surgery: a systematic review and meta-analysis

Ewan D Kennedy, Kevin C C Choy, R Peter Alston, Shaoyun Chen, Muhamed M H Farhan-Alanie, Jamie Anderson, Yun Lin Ang, Deborah E Moore, Sam A Mackenzie, Robert A Sykes

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

OBJECTIVE: The aim of this study was to compare cognition following coronary artery bypass grafting (CABG) surgery with or without cardiopulmonary bypass (CPB) (on- or off-pump).

DESIGN: Systematic review and meta-analysis of randomized control trials comparing cognitive outcome in patients undergoing CABG surgery on- or off-pump as assessed by continuous measures from a battery of 7 psychometric tests.

SETTING: Multi-institutional centers performing CABG surgery.

PARTICIPANTS: Patients with coronary artery disease requiring CABG surgery.

INTERVENTIONS: CABG surgery with or without CPB.

MEASUREMENTS AND MAIN RESULTS: A structured literature search identified 13 randomized control trials that included a total of 2,405 patients. Results from 7 psychometric tests were grouped into early (≤3 months) and late (6-12 months) postoperative periods. No significant differences were found between on- and off-pump groups in any of the 7 psychometric tests in either the early (p range 0.21-0.78) or late (p range 0.09-0.93) postoperative period.

CONCLUSION: The results suggested that CPB may not be associated with cognitive decline that is associated with CABG surgery.

Original languageEnglish
Pages (from-to)253-65
Number of pages13
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number2
Publication statusPublished - Apr 2013

Keywords / Materials (for Non-textual outputs)

  • Cognition
  • Cognition Disorders
  • Coronary Artery Bypass, Off-Pump
  • Endpoint Determination
  • Humans
  • Learning
  • Memory
  • Neuropsychological Tests
  • Postoperative Period
  • Psychometrics
  • Publication Bias
  • Randomized Controlled Trials as Topic
  • Trail Making Test
  • Treatment Outcome
  • Journal Article
  • Meta-Analysis
  • Review


Dive into the research topics of 'Cognitive outcome after on- and off-pump coronary artery bypass grafting surgery: a systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this