Abstract
OBJECTIVE: The aim of this study was to compare cognition following coronary artery bypass grafting (CABG) surgery with or without cardiopulmonary bypass (CPB) (on- or off-pump).
DESIGN: Systematic review and meta-analysis of randomized control trials comparing cognitive outcome in patients undergoing CABG surgery on- or off-pump as assessed by continuous measures from a battery of 7 psychometric tests.
SETTING: Multi-institutional centers performing CABG surgery.
PARTICIPANTS: Patients with coronary artery disease requiring CABG surgery.
INTERVENTIONS: CABG surgery with or without CPB.
MEASUREMENTS AND MAIN RESULTS: A structured literature search identified 13 randomized control trials that included a total of 2,405 patients. Results from 7 psychometric tests were grouped into early (≤3 months) and late (6-12 months) postoperative periods. No significant differences were found between on- and off-pump groups in any of the 7 psychometric tests in either the early (p range 0.21-0.78) or late (p range 0.09-0.93) postoperative period.
CONCLUSION: The results suggested that CPB may not be associated with cognitive decline that is associated with CABG surgery.
Original language | English |
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Pages (from-to) | 253-65 |
Number of pages | 13 |
Journal | Journal of Cardiothoracic and Vascular Anesthesia |
Volume | 27 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2013 |
Keywords / Materials (for Non-textual outputs)
- Cognition
- Cognition Disorders
- Coronary Artery Bypass, Off-Pump
- Endpoint Determination
- Humans
- Learning
- Memory
- Neuropsychological Tests
- Postoperative Period
- Psychometrics
- Publication Bias
- Randomized Controlled Trials as Topic
- Trail Making Test
- Treatment Outcome
- Journal Article
- Meta-Analysis
- Review