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Abstract
Cohesin is a multi-subunit molecular machine that is able to create lateral chromatin loops within a linear chromosome fiber. Despite intense study, a consensus view of the functional significance of loop extrusion has remained elusive. This perspective proposes a rationale based on the need for continual disruption of spurious higher-order chromatin secondary structures. It is argued that cohesin-mediated chromosomal churn ensures broad accessibility to the diffusible factors on which genome function depends.
Original language | English |
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Number of pages | 11 |
Journal | Molecular Cell |
Early online date | 4 Feb 2025 |
DOIs | |
Publication status | E-pub ahead of print - 4 Feb 2025 |
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- 1 Finished