Cohesin as an essential disruptor of chromosome organization

Adrian Bird*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Cohesin is a multi-subunit molecular machine that is able to create lateral chromatin loops within a linear chromosome fiber. Despite intense study, a consensus view of the functional significance of loop extrusion has remained elusive. This perspective proposes a rationale based on the need for continual disruption of spurious higher-order chromatin secondary structures. It is argued that cohesin-mediated chromosomal churn ensures broad accessibility to the diffusible factors on which genome function depends.
Original languageEnglish
Number of pages11
JournalMolecular Cell
Early online date4 Feb 2025
DOIs
Publication statusE-pub ahead of print - 4 Feb 2025

Fingerprint

Dive into the research topics of 'Cohesin as an essential disruptor of chromosome organization'. Together they form a unique fingerprint.

Cite this