Cohesin as an essential disruptor of chromosome organization

Adrian Bird

doi:10.1016/j.molcel.2025.01.010

Cohesin as an essential disruptor of chromosome organization

Adrian Bird^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Cohesin is a multi-subunit molecular machine that is able to create lateral chromatin loops within a linear chromosome fiber. Despite intense study, a consensus view of the functional significance of loop extrusion has remained elusive. This perspective proposes a rationale based on the need for continual disruption of spurious higher-order chromatin secondary structures. It is argued that cohesin-mediated chromosomal churn ensures broad accessibility to the diffusible factors on which genome function depends.

Original language	English
Pages (from-to)	1054-1057
Number of pages	11
Journal	Molecular Cell
Volume	85
Issue number	6
Early online date	4 Feb 2025
DOIs	https://doi.org/10.1016/j.molcel.2025.01.010
Publication status	Published - 20 Mar 2025

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10.1016/j.molcel.2025.01.010Licence: Creative Commons: Attribution (CC-BY)

PIIS1097276525000449Final published version, 263 KBLicence: CC BY

Towards understanding and treatment of MeCP2-related disorders
Bird, A. (Principal Investigator)
Wellcome Trust (Rcl)
1/01/16 → 30/06/22
Project: Research

Cite this

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title = "Cohesin as an essential disruptor of chromosome organization",

abstract = "Cohesin is a multi-subunit molecular machine that is able to create lateral chromatin loops within a linear chromosome fiber. Despite intense study, a consensus view of the functional significance of loop extrusion has remained elusive. This perspective proposes a rationale based on the need for continual disruption of spurious higher-order chromatin secondary structures. It is argued that cohesin-mediated chromosomal churn ensures broad accessibility to the diffusible factors on which genome function depends.",

author = "Adrian Bird",

note = "Dedicated to the memory of Joseph G. Gall (1928–2024), pioneer in chromosome biology. I am grateful to Drs A. Jackson, A. Marston, K. Nasmyth and E. Heard for helpful comments on the manuscript. ",

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PY - 2025/3/20

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N2 - Cohesin is a multi-subunit molecular machine that is able to create lateral chromatin loops within a linear chromosome fiber. Despite intense study, a consensus view of the functional significance of loop extrusion has remained elusive. This perspective proposes a rationale based on the need for continual disruption of spurious higher-order chromatin secondary structures. It is argued that cohesin-mediated chromosomal churn ensures broad accessibility to the diffusible factors on which genome function depends.

AB - Cohesin is a multi-subunit molecular machine that is able to create lateral chromatin loops within a linear chromosome fiber. Despite intense study, a consensus view of the functional significance of loop extrusion has remained elusive. This perspective proposes a rationale based on the need for continual disruption of spurious higher-order chromatin secondary structures. It is argued that cohesin-mediated chromosomal churn ensures broad accessibility to the diffusible factors on which genome function depends.

U2 - 10.1016/j.molcel.2025.01.010

DO - 10.1016/j.molcel.2025.01.010

M3 - Review article

SN - 1097-2765

VL - 85

SP - 1054

EP - 1057

JO - Molecular Cell

JF - Molecular Cell

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Cohesin as an essential disruptor of chromosome organization

Abstract

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Towards understanding and treatment of MeCP2-related disorders

Cite this