COLLABORATIVE UK STUDY OF CHRONIC HEPATITIS B VIRUS INFECTION: 45th Annual Meeting of the European-Association-for-the-Study-of-the-Liver

L. Fries, A. Rodger, G. Dusheiko, S. Ijaz, R. Tedder, J. Banatvala, R. Williams, N. Naoumov, S. Puranik, S. Chokshi, T. Wong, W. Rosenberg, S. Moreea, A. Bathgate, M. Jacobs, P. Mills, D. Mutimer, M. Bassendine, S. Ryder, M. ThurszA. Johnson

Research output: Contribution to journalMeeting abstractpeer-review

Abstract

Background and Aims:Chronic hepatitis B virus (HBV) is animportant health problem in the UK with an estimated 180,000to 325,000 people infected and at risk of long-term liver sequelae.We aim to establish a national database of chronic HBV patientsfor long-term follow-up to provide comprehensive data on naturalhistory, clinical management and virological characteristics ofchronic HBV.Methods:Adult patients with chronic HBV under active follow-upin 15 UK centres were eligible for enrolment. Demographic, clinicaland laboratory data were collected. HBV DNA amplification anddirect sequencing were undertaken in a subset of patients.Results:637 individuals are currently registered in the cohort.Median age is 41 years (IQR 33–51years) and 57% are male.Predominant ethnicities are white (27%), Chinese (21%), blackAfrican (18%) and Pakistani (12%). The majority (85%; n=557) wereborn outside of the UK. 20% (115/569) are HBeAg positive and80% (448/560) anti-HBe positive. HBV DNA was detected in 74%.Over a third (35%; 215/613) are currently on antiviral nucleos(t)ideanalogues or interferon and 14% (77/543) had been previously.Analysis of the subset sequenced (n=188) indicated 14%, 21%,27%, 29%, and 8.5% to be genotypes A to E respectively, with 0.5%genotype G. Most common genotypes were A (44%) and D (47%)in whites, B (40%) and C (50%) in Chinese, D (90%) in Pakistanis,and A (23%) and E (46%) in black Africans. 61% had mutations inthe precore region only, associated with the inhibition of HBeAgsynthesis. 9% of the samples carried T1762/A1764 mutations onanalysis of the basal core promoter (BCP) region. A further 8%carried both precore and BCP mutations. Of 47 samples currentlyon/or previously on nucleos(t)ides, 19% bore antiviral resistancemutations.Conclusions:In patients enrolled in our national HBV cohort,genotypic distribution and ethnicity data confirms immigrantpopulations are most at risk of HBV infection. One fifth hadmutations associated with antiviral resistance demonstrating thepotential utility of this database to monitor emergence of resistancein clinical practice which may differ from trial data. We aim torecruit into the cohort approximately 5,000 patients for long-termprospective follow-up
Original languageEnglish
Pages (from-to)S278-S278
JournalJournal of Hepatology
Volume52
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • Science & Technology
  • Life Sciences & Biomedicine
  • Gastroenterology & Hepatology

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