TY - JOUR
T1 - Colorectal cancer susceptibility loci in a population-based study
T2 - Associations with morphological parameters
AU - Low Risk Colorectal Canc Study Grp
AU - Ghazi, Sam
AU - von Holst, Susanna
AU - Picelli, Simone
AU - Lindforss, Ulnk
AU - Tenesa, Albert
AU - Famngton, Susan M.
AU - Campbell, Harry
AU - Dunlop, Malcolm G.
AU - Papadogiannakis, Nikos
AU - Lindblom, Annika
PY - 2010/12
Y1 - 2010/12
N2 - Recent genome wide association studies have identified multiple genetic loci and single nucleotide polymorphisms (SNPs) associated with either increased or de creased risk of colorectal cancer (CRC) In the present study our objective was to determine whether 11 of the new susceptibility CRC loci are associated with tumor morphology and to confirm these loci as distinct and etiologically different risk factors in the development of CRC The following clinical and morphological parameters were analyzed in 1572 samples tumor size T stage lymph node metastases degree of differentiation mucin production Crohn like peritumoral lymphocytic infiltration tumor infiltrating lymphocytes desmoplastic reaction necrosis invasion of blood or lymph vessels perineural growth medullary type budding and tumor margin One SNP from each of the 11 loci (rs6983267 on 8q24 21 rs16892766 on 8q23 3 rs719725 on 9p24 1 rs10795668 on 10p14 rs3802842 on 11q23 1 rs4444235 on 14q22 2 rs4779584 on 15q13 3 rs9929218 on 16q22 1 rs4939827 on 18q21 1 rs10411210 on 19q13 11 and rs961253 on 20p12 3) was genotyped for all cases Odds ratios 95% confidence intervals and the corresponding P values were calculated for the 11 SNPs identified above A cross tabulation between SNPs and morphology was performed Several loci showed statistically significant associations with specific phenotypes The findings are consistent with pathogenic variants in several loci that act in distinct CRC and morphogenetic pathways Further large scale studies are required to validate these findings (Am J Pathol 2010 177 2688-2693, DOI 10 2353/ajpath 2010 100298)
AB - Recent genome wide association studies have identified multiple genetic loci and single nucleotide polymorphisms (SNPs) associated with either increased or de creased risk of colorectal cancer (CRC) In the present study our objective was to determine whether 11 of the new susceptibility CRC loci are associated with tumor morphology and to confirm these loci as distinct and etiologically different risk factors in the development of CRC The following clinical and morphological parameters were analyzed in 1572 samples tumor size T stage lymph node metastases degree of differentiation mucin production Crohn like peritumoral lymphocytic infiltration tumor infiltrating lymphocytes desmoplastic reaction necrosis invasion of blood or lymph vessels perineural growth medullary type budding and tumor margin One SNP from each of the 11 loci (rs6983267 on 8q24 21 rs16892766 on 8q23 3 rs719725 on 9p24 1 rs10795668 on 10p14 rs3802842 on 11q23 1 rs4444235 on 14q22 2 rs4779584 on 15q13 3 rs9929218 on 16q22 1 rs4939827 on 18q21 1 rs10411210 on 19q13 11 and rs961253 on 20p12 3) was genotyped for all cases Odds ratios 95% confidence intervals and the corresponding P values were calculated for the 11 SNPs identified above A cross tabulation between SNPs and morphology was performed Several loci showed statistically significant associations with specific phenotypes The findings are consistent with pathogenic variants in several loci that act in distinct CRC and morphogenetic pathways Further large scale studies are required to validate these findings (Am J Pathol 2010 177 2688-2693, DOI 10 2353/ajpath 2010 100298)
UR - http://www.scopus.com/inward/record.url?scp=78650205592&partnerID=8YFLogxK
U2 - 10.2353/ajpath.2010.100298
DO - 10.2353/ajpath.2010.100298
M3 - Article
C2 - 21119214
SN - 0002-9440
VL - 177
SP - 2688
EP - 2693
JO - The American Journal of Pathology
JF - The American Journal of Pathology
IS - 6
ER -