Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Linda Ejim, Maya A Farha, Shannon B Falconer, Jan Wildenhain, Brian K Coombes, Mike Tyers, Eric D Brown, Gerard D Wright

Research output: Contribution to journalArticlepeer-review

Abstract

Combinations of antibiotics are commonly used in medicine to broaden antimicrobial spectrum and generate synergistic effects. Alternatively, combination of nonantibiotic drugs with antibiotics offers an opportunity to sample a previously untapped expanse of bioactive chemical space. We screened a collection of drugs to identify compounds that augment the activity of the antibiotic minocycline. Unexpected synergistic drug combinations exhibited in vitro and in vivo activity against bacterial pathogens, including multidrug-resistant isolates.
Original languageEnglish
Pages (from-to)348-350
Number of pages3
JournalNature Chemical Biology
Volume7
Issue number6
DOIs
Publication statusPublished - Jun 2011

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