Abstract / Description of output
A synthetic methodology to prepare collections of trisubstituted aryl 1,3,5-triazines with broad structural diversity via Suzuki coupling has been developed. We first optimized the combinatorial derivatization of the triazine core using Suzuki cross-coupling. Second, in order to further expand the methodology for the preparation of negatively charged triazines, we adapted this approach to polymer-supported amino acids and prepared aryl triazines with different charge distribution. With a collection of 160 aryl triazine derivatives in good purities and without any purification step, we proved the viability of this orthogonal scheme for the preparation of triazine libraries using amine/amino acid-captured solid supports and Suzuki cross-coupling.
Original language | English |
---|---|
Pages (from-to) | 540-544 |
Number of pages | 5 |
Journal | Australian Journal of Chemistry |
Volume | 64 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2011 |
Keywords / Materials (for Non-textual outputs)
- ORTHOGONAL SYNTHESIS
- TRIAZINE LIBRARY
- ANTITUMOR EVALUATION
- KINASE INHIBITORS
- SERIES
- HETEROCYCLES
- DERIVATIVES
- MODULATORS
- ANALOGS