Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells

Svetlana Myssina; G Vignir Helgason; Alan Serrels; Heather G Jørgensen; Ravi Bhatia; Hardik Modi; Janet W Baird; Joanne C Mountford; Ashley Hamilton; Mirle Schemionek; Steffen Koschmieder; Valerie G Brunton; Tessa L Holyoake

doi:10.1016/j.exphem.2008.10.013

Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells

Svetlana Myssina, G Vignir Helgason, Alan Serrels, Heather G Jørgensen, Ravi Bhatia, Hardik Modi, Janet W Baird, Joanne C Mountford, Ashley Hamilton, Mirle Schemionek, Steffen Koschmieder, Valerie G Brunton, Tessa L Holyoake

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigated two approaches, short hairpin RNA (shRNA) and the potent ABL inhibitor, dasatinib, alone and together, to achieve complete inhibition of BCR-ABL activity in Philadelphia-positive (Ph(+)) cells.

Original language	English
Pages (from-to)	206-14
Number of pages	9
Journal	Experimental Hematology
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/j.exphem.2008.10.013
Publication status	Published - 2009

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Myssina, S., Helgason, G. V., Serrels, A., Jørgensen, H. G., Bhatia, R., Modi, H., Baird, J. W., Mountford, J. C., Hamilton, A., Schemionek, M., Koschmieder, S., Brunton, V. G., & Holyoake, T. L. (2009). Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells. Experimental Hematology, 37(2), 206-14. https://doi.org/10.1016/j.exphem.2008.10.013

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title = "Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells",

abstract = "This study investigated two approaches, short hairpin RNA (shRNA) and the potent ABL inhibitor, dasatinib, alone and together, to achieve complete inhibition of BCR-ABL activity in Philadelphia-positive (Ph(+)) cells.",

author = "Svetlana Myssina and Helgason, \{G Vignir\} and Alan Serrels and J{\o}rgensen, \{Heather G\} and Ravi Bhatia and Hardik Modi and Baird, \{Janet W\} and Mountford, \{Joanne C\} and Ashley Hamilton and Mirle Schemionek and Steffen Koschmieder and Brunton, \{Valerie G\} and Holyoake, \{Tessa L\}",

year = "2009",

doi = "10.1016/j.exphem.2008.10.013",

language = "English",

volume = "37",

pages = "206--14",

journal = "Experimental Hematology",

publisher = "Elsevier",

number = "2",

}

Myssina, S, Helgason, GV, Serrels, A, Jørgensen, HG, Bhatia, R, Modi, H, Baird, JW, Mountford, JC, Hamilton, A, Schemionek, M, Koschmieder, S, Brunton, VG & Holyoake, TL 2009, 'Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells', Experimental Hematology, vol. 37, no. 2, pp. 206-14. https://doi.org/10.1016/j.exphem.2008.10.013

TY - JOUR

T1 - Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells

AU - Myssina, Svetlana

AU - Helgason, G Vignir

AU - Serrels, Alan

AU - Jørgensen, Heather G

AU - Bhatia, Ravi

AU - Modi, Hardik

AU - Baird, Janet W

AU - Mountford, Joanne C

AU - Hamilton, Ashley

AU - Schemionek, Mirle

AU - Koschmieder, Steffen

AU - Brunton, Valerie G

AU - Holyoake, Tessa L

PY - 2009

Y1 - 2009

N2 - This study investigated two approaches, short hairpin RNA (shRNA) and the potent ABL inhibitor, dasatinib, alone and together, to achieve complete inhibition of BCR-ABL activity in Philadelphia-positive (Ph(+)) cells.

AB - This study investigated two approaches, short hairpin RNA (shRNA) and the potent ABL inhibitor, dasatinib, alone and together, to achieve complete inhibition of BCR-ABL activity in Philadelphia-positive (Ph(+)) cells.

UR - https://www.scopus.com/pages/publications/58149181327

U2 - 10.1016/j.exphem.2008.10.013

DO - 10.1016/j.exphem.2008.10.013

M3 - Article

C2 - 19100678

VL - 37

SP - 206

EP - 214

JO - Experimental Hematology

JF - Experimental Hematology

IS - 2

ER -

Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells

Abstract

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