Combined sequence-based and genetic mapping analysis of complex traits in outbred rats

Rat Genome Sequencing and Mapping Consortium, Amelie Baud, Roel Hermsen, Victor Guryev, Pernilla Stridh, Delyth Graham, Martin W McBride, Tatiana Foroud, Sophie Calderari, Margarita Diez, Johan Ockinger, Amennai D Beyeen, Alan Gillett, Nada Abdelmagid, Andre Ortlieb Guerreiro-Cacais, Maja Jagodic, Jonatan Tuncel, Ulrika Norin, Elisabeth Beattie, Ngan HuynhWilliam H Miller, Daniel L Koller, Imranul Alam, Samreen Falak, Mary Osborne-Pellegrin, Esther Martinez-Membrives, Toni Canete, Gloria Blazquez, Elia Vicens-Costa, Carme Mont-Cardona, Sira Diaz-Moran, Adolf Tobena, Oliver Hummel, Diana Zelenika, Kathrin Saar, Giannino Patone, Anja Bauerfeind, Marie-Therese Bihoreau, Matthias Heinig, Young-Ae Lee, Carola Rintisch, Herbert Schulz, David A Wheeler, Kim C Worley, Donna M Muzny, Richard A Gibbs, Mark Lathrop, Nico Lansu, Pim Toonen, Santosh S Atanur, Tim J Aitman

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Genetic mapping on fully sequenced individuals is transforming understanding of the relationship between molecular variation and variation in complex traits. Here we report a combined sequence and genetic mapping analysis in outbred rats that maps 355 quantitative trait loci for 122 phenotypes. We identify 35 causal genes involved in 31 phenotypes, implicating new genes in models of anxiety, heart disease and multiple sclerosis. The relationship between sequence and genetic variation is unexpectedly complex: at approximately 40% of quantitative trait loci, a single sequence variant cannot account for the phenotypic effect. Using comparable sequence and mapping data from mice, we show that the extent and spatial pattern of variation in inbred rats differ substantially from those of inbred mice and that the genetic variants in orthologous genes rarely contribute to the same phenotype in both species.

Original languageEnglish
Pages (from-to)767-75
Number of pages9
JournalNature Genetics
Volume45
Issue number7
DOIs
Publication statusPublished - Jul 2013

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Animals, Outbred Strains
  • Anxiety
  • Chromosome Mapping
  • Genetic Variation
  • Genotype
  • Heart Diseases
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Models, Molecular
  • Multiple Sclerosis
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci
  • Rats
  • Sequence Analysis, DNA

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