Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint"

Stephen S Taylor; Kevin G Hardwick; Kenneth E Sawin; Sue Biggins; Simonetta Piatti; Alexey Khodjakov; Conly L Rieder; Edward D Salmon; Andrea Musacchio

doi:10.1126/science.1139484

Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint"

Stephen S Taylor, Kevin G Hardwick, Kenneth E Sawin, Sue Biggins, Simonetta Piatti, Alexey Khodjakov, Conly L Rieder, Edward D Salmon, Andrea Musacchio

School of Biological Sciences

Research output: Contribution to journal › Comment/debate › peer-review

Abstract / Description of output

Müller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the gamma-tubulin ring complex (gamma-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that gamma-TuRC proteins play molecular roles in SAC activation. Because gamma-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature.

Original language	English
Pages (from-to)	982
Number of pages	1
Journal	Science
Volume	316
Issue number	5827
DOIs	https://doi.org/10.1126/science.1139484
Publication status	Published - 2007

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Analysis of mitosis and spindle check point in yeast and frogs
Hardwick, K.
UK-based charities
1/10/00 → 31/05/08
Project: Research

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title = "Comment on {"}A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint{"}",

abstract = "M{\"u}ller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the gamma-tubulin ring complex (gamma-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that gamma-TuRC proteins play molecular roles in SAC activation. Because gamma-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature.",

author = "Taylor, {Stephen S} and Hardwick, {Kevin G} and Sawin, {Kenneth E} and Sue Biggins and Simonetta Piatti and Alexey Khodjakov and Rieder, {Conly L} and Salmon, {Edward D} and Andrea Musacchio",

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language = "English",

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T1 - Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint"

AU - Taylor, Stephen S

AU - Hardwick, Kevin G

AU - Sawin, Kenneth E

AU - Biggins, Sue

AU - Piatti, Simonetta

AU - Khodjakov, Alexey

AU - Rieder, Conly L

AU - Salmon, Edward D

AU - Musacchio, Andrea

PY - 2007

Y1 - 2007

N2 - Müller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the gamma-tubulin ring complex (gamma-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that gamma-TuRC proteins play molecular roles in SAC activation. Because gamma-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature.

AB - Müller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the gamma-tubulin ring complex (gamma-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that gamma-TuRC proteins play molecular roles in SAC activation. Because gamma-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature.

U2 - 10.1126/science.1139484

DO - 10.1126/science.1139484

M3 - Comment/debate

C2 - 17510347

SN - 0036-8075

VL - 316

SP - 982

JO - Science

JF - Science

IS - 5827

ER -

Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint"

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Analysis of mitosis and spindle check point in yeast and frogs

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