Comment on "Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells"

Bilada Bilican; Andrea Serio; Sami J Barmada; Agnes Lumi Nishimura; Gareth J Sullivan; Monica Carrasco; Hemali P Phatnani; Clare A Puddifoot; David Story; Judy Fletcher; In-Hyun Park; Brad A Friedman; George Q Daley; David J A Wyllie; Giles E Hardingham; Ian Wilmut; Steven Finkbeiner; Tom Maniatis; Christopher E Shaw; Siddharthan Chandran

doi:10.1126/scitranslmed.3005065

Comment on "Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells"

Bilada Bilican, Andrea Serio, Sami J Barmada, Agnes Lumi Nishimura, Gareth J Sullivan, Monica Carrasco, Hemali P Phatnani, Clare A Puddifoot, David Story, Judy Fletcher, In-Hyun Park, Brad A Friedman, George Q Daley, David J A Wyllie, Giles E Hardingham, Ian Wilmut, Steven Finkbeiner, Tom Maniatis, Christopher E Shaw, Siddharthan Chandran

Research output: Contribution to journal › Letter

Abstract / Description of output

Egawa et al. recently showed the value of patient-specific induced pluripotent stem cells (iPSCs) for modeling amyotrophic lateral sclerosis in vitro. Their study and our work highlight the need for complementary assays to detect small, but potentially important, phenotypic differences between control iPSC lines and those carrying disease mutations.

Original language	English
Article number	188le2
Journal	Science Translational Medicine
Volume	5
Issue number	188
DOIs	https://doi.org/10.1126/scitranslmed.3005065
Publication status	Published - 5 Jun 2013

Keywords / Materials (for Non-textual outputs)

Amyotrophic Lateral Sclerosis
Drug Evaluation, Preclinical
humans
induced pluripotent stem cell
motor neurons

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Comment on “Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells”Accepted author manuscript, 192 KB

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Bilican, B., Serio, A., Barmada, S. J., Nishimura, A. L., Sullivan, G. J., Carrasco, M., Phatnani, H. P., Puddifoot, C. A., Story, D., Fletcher, J., Park, I.-H., Friedman, B. A., Daley, G. Q., Wyllie, D. J. A., Hardingham, G. E., Wilmut, I., Finkbeiner, S., Maniatis, T., Shaw, C. E., & Chandran, S. (2013). Comment on "Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells". Science Translational Medicine, 5(188), Article 188le2. https://doi.org/10.1126/scitranslmed.3005065

@article{b2bf8dbe2b62485282da79e26d401594,

title = "Comment on {"}Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells{"}",

abstract = "Egawa et al. recently showed the value of patient-specific induced pluripotent stem cells (iPSCs) for modeling amyotrophic lateral sclerosis in vitro. Their study and our work highlight the need for complementary assays to detect small, but potentially important, phenotypic differences between control iPSC lines and those carrying disease mutations.",

keywords = "Amyotrophic Lateral Sclerosis, Drug Evaluation, Preclinical, humans, induced pluripotent stem cell, motor neurons ",

author = "Bilada Bilican and Andrea Serio and Barmada, {Sami J} and Nishimura, {Agnes Lumi} and Sullivan, {Gareth J} and Monica Carrasco and Phatnani, {Hemali P} and Puddifoot, {Clare A} and David Story and Judy Fletcher and In-Hyun Park and Friedman, {Brad A} and Daley, {George Q} and Wyllie, {David J A} and Hardingham, {Giles E} and Ian Wilmut and Steven Finkbeiner and Tom Maniatis and Shaw, {Christopher E} and Siddharthan Chandran",

note = "Copyright {\textcopyright} 2013, American Association for the Advancement of Science",

year = "2013",

month = jun,

day = "5",

doi = "10.1126/scitranslmed.3005065",

language = "English",

volume = "5",

journal = "Science Translational Medicine",

issn = "1946-6242",

publisher = "American Association for the Advancement of Science",

number = "188",

}

Bilican, B, Serio, A, Barmada, SJ, Nishimura, AL, Sullivan, GJ, Carrasco, M, Phatnani, HP, Puddifoot, CA, Story, D, Fletcher, J, Park, I-H, Friedman, BA, Daley, GQ, Wyllie, DJA , Hardingham, GE, Wilmut, I, Finkbeiner, S, Maniatis, T, Shaw, CE & Chandran, S 2013, 'Comment on "Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells"', Science Translational Medicine, vol. 5, no. 188, 188le2. https://doi.org/10.1126/scitranslmed.3005065

TY - JOUR

T1 - Comment on "Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells"

AU - Bilican, Bilada

AU - Serio, Andrea

AU - Barmada, Sami J

AU - Nishimura, Agnes Lumi

AU - Sullivan, Gareth J

AU - Carrasco, Monica

AU - Phatnani, Hemali P

AU - Puddifoot, Clare A

AU - Story, David

AU - Fletcher, Judy

AU - Park, In-Hyun

AU - Friedman, Brad A

AU - Daley, George Q

AU - Wyllie, David J A

AU - Hardingham, Giles E

AU - Wilmut, Ian

AU - Finkbeiner, Steven

AU - Maniatis, Tom

AU - Shaw, Christopher E

AU - Chandran, Siddharthan

PY - 2013/6/5

Y1 - 2013/6/5

N2 - Egawa et al. recently showed the value of patient-specific induced pluripotent stem cells (iPSCs) for modeling amyotrophic lateral sclerosis in vitro. Their study and our work highlight the need for complementary assays to detect small, but potentially important, phenotypic differences between control iPSC lines and those carrying disease mutations.

AB - Egawa et al. recently showed the value of patient-specific induced pluripotent stem cells (iPSCs) for modeling amyotrophic lateral sclerosis in vitro. Their study and our work highlight the need for complementary assays to detect small, but potentially important, phenotypic differences between control iPSC lines and those carrying disease mutations.

KW - Amyotrophic Lateral Sclerosis

KW - Drug Evaluation, Preclinical

KW - humans

KW - induced pluripotent stem cell

KW - motor neurons

U2 - 10.1126/scitranslmed.3005065

DO - 10.1126/scitranslmed.3005065

M3 - Letter

C2 - 23740897

SN - 1946-6242

VL - 5

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 188

M1 - 188le2

ER -

Comment on "Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells"

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Keywords / Materials (for Non-textual outputs)

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