Common and distinct neural correlates of emotional processing in Bipolar Disorder and Major Depressive Disorder: a voxel-based meta-analysis of functional magnetic resonance imaging studies

Giuseppe Delvecchio, Philippe Fossati, Patrice Boyer, Paolo Brambilla, Peter Falkai, Oliver Gruber, Jarmo Hietala, Stephen M. Lawrie, Jean-Luc Martinot, Andrew M. McIntosh, Eva Meisenzahl, Sophia Frangou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Neuroimaging studies have consistently shown functional brain abnormalities in patients with Bipolar Disorder (BD) and Major Depressive Disorder (MDD). However, the extent to which these two disorders are associated with similar or distinct neural changes remains unclear. We conducted a systematic review of functional magnetic resonance imaging studies comparing BD and MDD patients to healthy participants using facial affect processing paradigms. Relevant spatial coordinates from twenty original studies were subjected to quantitative Activation Likelihood Estimation meta-analyses based on 168 BD and 189 MDD patients and 344 healthy controls. We identified common and distinct patterns of neural engagement for BD and MDD within the facial affect processing network. Both disorders were associated with increased engagement of limbic regions. Diagnosis-specific differences were observed in cortical, thalamic and striatal regions. Decreased ventrolateral prefrontal cortical engagement was associated with BD while relative hypoactivation of the sensorimotor cortices was seen in MDD. Increased responsiveness in the thalamus and basal ganglia were associated with BD. These findings were modulated by stimulus valence. These data suggest that whereas limbic overactivation is reported consistently in patients with mood disorders, future research should consider the relevance of a wider network of regions in formulating conceptual models of BD and MDD.

Original languageEnglish
Pages (from-to)100-113
Number of pages14
JournalEuropean Neuropsychopharmacology
Volume22
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • SAD
  • Facial affect
  • NATURAL-HISTORY
  • Neuroimaging
  • FACIAL AFFECT RECOGNITION
  • WEEKLY SYMPTOMATIC STATUS
  • Bipolar Disorder
  • Meta-analysis
  • CORTICAL RESPONSES
  • ANTERIOR CINGULATE
  • ANTIDEPRESSANT TREATMENT
  • AMYGDALA ACTIVATION
  • UNIPOLAR DEPRESSION
  • Major Depressive Disorder
  • LAMOTRIGINE MONOTHERAPY
  • Mood disorders

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