Common genetic variants explain the majority of the correlation between height and intelligence: the generation Scotland study

Generation Scotland

doi:10.1007/s10519-014-9644-z

Common genetic variants explain the majority of the correlation between height and intelligence: the generation Scotland study

Generation Scotland

Research output: Contribution to journal › Article › peer-review

Abstract

Greater height and higher intelligence test scores are predictors of better health outcomes. Here, we used molecular (single-nucleotide polymorphism) data to estimate the genetic correlation between height and general intelligence (g) in 6,815 unrelated subjects (median age 57, IQR 49-63) from the Generation Scotland: Scottish Family Health Study cohort. The phenotypic correlation between height and g was 0.16 (SE 0.01). The genetic correlation between height and g was 0.28 (SE 0.09) with a bivariate heritability estimate of 0.71. Understanding the molecular basis of the correlation between height and intelligence may help explain any shared role in determining health outcomes. This study identified a modest genetic correlation between height and intelligence with the majority of the phenotypic correlation being explained by shared genetic influences.

Original language	English
Pages (from-to)	91-96
Number of pages	6
Journal	Behavior Genetics
Volume	44
Issue number	2
DOIs	https://doi.org/10.1007/s10519-014-9644-z
Publication status	Published - Mar 2014

Keywords / Materials (for Non-textual outputs)

Height
Intelligence
Molecular genetics
Genetic correlation
Generation Scotland
SCOTTISH FAMILY HEALTH
HERITABILITY
METAANALYSIS
ASSOCIATION
PLEIOTROPY
CHILDHOOD
DISEASE
SAMPLES
COHORT

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10.1007/s10519-014-9644-z

Common Genetic Variants Explain the Majority of the Correlation Between Height and Intelligence The Generation Scotland Study
Copyright © The Author(s) 2014 Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Final published version, 201 KBLicence: Creative Commons: Attribution (CC-BY)

http://link.springer.com/article/10.1007%2Fs10519-014-9644-z

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Maclullich, A.
1/09/13 → 31/08/19
Project: Research
RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
Project: Research
Generation Scotland
Porteous, D.
UK central government bodies/local authorities, health and hospital authorities
1/04/11 → 31/03/14
Project: Research

Cite this

@article{a81376bce2b04544b0d8c2df18f141cf,

title = "Common genetic variants explain the majority of the correlation between height and intelligence: the generation Scotland study",

abstract = "Greater height and higher intelligence test scores are predictors of better health outcomes. Here, we used molecular (single-nucleotide polymorphism) data to estimate the genetic correlation between height and general intelligence (g) in 6,815 unrelated subjects (median age 57, IQR 49-63) from the Generation Scotland: Scottish Family Health Study cohort. The phenotypic correlation between height and g was 0.16 (SE 0.01). The genetic correlation between height and g was 0.28 (SE 0.09) with a bivariate heritability estimate of 0.71. Understanding the molecular basis of the correlation between height and intelligence may help explain any shared role in determining health outcomes. This study identified a modest genetic correlation between height and intelligence with the majority of the phenotypic correlation being explained by shared genetic influences.",

keywords = "Height, Intelligence, Molecular genetics, Genetic correlation, Generation Scotland, SCOTTISH FAMILY HEALTH, HERITABILITY, METAANALYSIS, ASSOCIATION, PLEIOTROPY, CHILDHOOD, DISEASE, SAMPLES, COHORT",

author = "{Generation Scotland} and Marioni, {Riccardo E.} and Batty, {G. David} and Caroline Hayward and Kerr, {Shona M.} and Archie Campbell and Hocking, {Lynne J.} and Porteous, {David J.} and Visscher, {Peter M.} and Deary, {Ian J.}",

note = "Acknowledgments Generation Scotland has received core funding from the Chief Scientist Office of the Scottish Government Health Directorates CZD/16/6 and the Scottish Funding Council HR03006. Genotyping of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Wellcome Trust Clinical Research Facility, Edinburgh, Scotland and was funded by the UK Medical Research Council (MRC). The Quantitative Trait Locus team at the Human Genetics Unit are funded by the MRC. IJD and GDB are members of the Alzheimer Scotland Dementia Research Centre funded by Alzheimer Scotland. REM, GDB, DJP, PMV, and IJD undertook the work within The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology (MR/K026992/1), part of the cross council Lifelong Health and Wellbeing Initiative. Funding from the BBSRC, and MRC is gratefully acknowledged.",

year = "2014",

month = mar,

doi = "10.1007/s10519-014-9644-z",

language = "English",

volume = "44",

pages = "91--96",

journal = "Behavior Genetics",

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AU - Generation Scotland

AU - Marioni, Riccardo E.

AU - Batty, G. David

AU - Hayward, Caroline

AU - Kerr, Shona M.

AU - Campbell, Archie

AU - Hocking, Lynne J.

AU - Porteous, David J.

AU - Visscher, Peter M.

AU - Deary, Ian J.

N1 - Acknowledgments Generation Scotland has received core funding from the Chief Scientist Office of the Scottish Government Health Directorates CZD/16/6 and the Scottish Funding Council HR03006. Genotyping of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Wellcome Trust Clinical Research Facility, Edinburgh, Scotland and was funded by the UK Medical Research Council (MRC). The Quantitative Trait Locus team at the Human Genetics Unit are funded by the MRC. IJD and GDB are members of the Alzheimer Scotland Dementia Research Centre funded by Alzheimer Scotland. REM, GDB, DJP, PMV, and IJD undertook the work within The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology (MR/K026992/1), part of the cross council Lifelong Health and Wellbeing Initiative. Funding from the BBSRC, and MRC is gratefully acknowledged.

PY - 2014/3

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N2 - Greater height and higher intelligence test scores are predictors of better health outcomes. Here, we used molecular (single-nucleotide polymorphism) data to estimate the genetic correlation between height and general intelligence (g) in 6,815 unrelated subjects (median age 57, IQR 49-63) from the Generation Scotland: Scottish Family Health Study cohort. The phenotypic correlation between height and g was 0.16 (SE 0.01). The genetic correlation between height and g was 0.28 (SE 0.09) with a bivariate heritability estimate of 0.71. Understanding the molecular basis of the correlation between height and intelligence may help explain any shared role in determining health outcomes. This study identified a modest genetic correlation between height and intelligence with the majority of the phenotypic correlation being explained by shared genetic influences.

AB - Greater height and higher intelligence test scores are predictors of better health outcomes. Here, we used molecular (single-nucleotide polymorphism) data to estimate the genetic correlation between height and general intelligence (g) in 6,815 unrelated subjects (median age 57, IQR 49-63) from the Generation Scotland: Scottish Family Health Study cohort. The phenotypic correlation between height and g was 0.16 (SE 0.01). The genetic correlation between height and g was 0.28 (SE 0.09) with a bivariate heritability estimate of 0.71. Understanding the molecular basis of the correlation between height and intelligence may help explain any shared role in determining health outcomes. This study identified a modest genetic correlation between height and intelligence with the majority of the phenotypic correlation being explained by shared genetic influences.

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KW - Intelligence

KW - Molecular genetics

KW - Genetic correlation

KW - Generation Scotland

KW - SCOTTISH FAMILY HEALTH

KW - HERITABILITY

KW - METAANALYSIS

KW - ASSOCIATION

KW - PLEIOTROPY

KW - CHILDHOOD

KW - DISEASE

KW - SAMPLES

KW - COHORT

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JO - Behavior Genetics

JF - Behavior Genetics

IS - 2

ER -

Common genetic variants explain the majority of the correlation between height and intelligence: the generation Scotland study

Abstract

Keywords / Materials (for Non-textual outputs)

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Projects

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

Generation Scotland

Cite this