Common variants in WFS1 confer risk of type 2 diabetes

Manjinder S. Sandhu; Michael N. Weedon; Katherine A. Fawcett; Jon Wasson; Sally L. Debenham; Allan Daly; Hana Lango; Timothy M. Frayling; Rosalind J. Neumann; Richard Sherva; Ilana Blech; Paul D. Pharoah; Colin N A Palmer; Charlotte Kimber; Roger Tavendale; Andrew D. Morris; Mark I. McCarthy; Mark Walker; Graham Hitman; Benjamin Glaser; M. Alan Permutt; Andrew T. Hattersley; Nicholas J. Wareham; Inês Barroso

doi:10.1038/ng2067

Common variants in WFS1 confer risk of type 2 diabetes

Manjinder S. Sandhu^*, Michael N. Weedon, Katherine A. Fawcett, Jon Wasson, Sally L. Debenham, Allan Daly, Hana Lango, Timothy M. Frayling, Rosalind J. Neumann, Richard Sherva, Ilana Blech, Paul D. Pharoah, Colin N A Palmer, Charlotte Kimber, Roger Tavendale, Andrew D. Morris, Mark I. McCarthy, Mark Walker, Graham Hitman, Benjamin GlaserM. Alan Permutt, Andrew T. Hattersley, Nicholas J. Wareham, Inês Barroso

^*Corresponding author for this work

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.

Original language	English
Pages (from-to)	951-953
Number of pages	3
Journal	Nature Genetics
Volume	39
Issue number	8
DOIs	https://doi.org/10.1038/ng2067
Publication status	Published - 1 Aug 2007

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10.1038/ng2067

Common variants in WFS1 confer risk of type 2 diabetes
Published in final edited form as: Nat Genet. Aug 2007; 39(8): 951–953.
Accepted author manuscript, 272 KB

http://www.nature.com/ng/journal/v39/n8/full/ng2067.html

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Sandhu, M. S., Weedon, M. N., Fawcett, K. A., Wasson, J., Debenham, S. L., Daly, A., Lango, H., Frayling, T. M., Neumann, R. J., Sherva, R., Blech, I., Pharoah, P. D., Palmer, C. N. A., Kimber, C., Tavendale, R., Morris, A. D., McCarthy, M. I., Walker, M., Hitman, G., ... Barroso, I. (2007). Common variants in WFS1 confer risk of type 2 diabetes. Nature Genetics, 39(8), 951-953. https://doi.org/10.1038/ng2067

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title = "Common variants in WFS1 confer risk of type 2 diabetes",

abstract = "We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.",

author = "Sandhu, {Manjinder S.} and Weedon, {Michael N.} and Fawcett, {Katherine A.} and Jon Wasson and Debenham, {Sally L.} and Allan Daly and Hana Lango and Frayling, {Timothy M.} and Neumann, {Rosalind J.} and Richard Sherva and Ilana Blech and Pharoah, {Paul D.} and Palmer, {Colin N A} and Charlotte Kimber and Roger Tavendale and Morris, {Andrew D.} and McCarthy, {Mark I.} and Mark Walker and Graham Hitman and Benjamin Glaser and Permutt, {M. Alan} and Hattersley, {Andrew T.} and Wareham, {Nicholas J.} and In{\^e}s Barroso",

year = "2007",

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doi = "10.1038/ng2067",

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Sandhu, MS, Weedon, MN, Fawcett, KA, Wasson, J, Debenham, SL, Daly, A, Lango, H, Frayling, TM, Neumann, RJ, Sherva, R, Blech, I, Pharoah, PD, Palmer, CNA, Kimber, C, Tavendale, R, Morris, AD, McCarthy, MI, Walker, M, Hitman, G, Glaser, B, Permutt, MA, Hattersley, AT, Wareham, NJ & Barroso, I 2007, 'Common variants in WFS1 confer risk of type 2 diabetes', Nature Genetics, vol. 39, no. 8, pp. 951-953. https://doi.org/10.1038/ng2067

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AU - Sandhu, Manjinder S.

AU - Weedon, Michael N.

AU - Fawcett, Katherine A.

AU - Wasson, Jon

AU - Debenham, Sally L.

AU - Daly, Allan

AU - Lango, Hana

AU - Frayling, Timothy M.

AU - Neumann, Rosalind J.

AU - Sherva, Richard

AU - Blech, Ilana

AU - Pharoah, Paul D.

AU - Palmer, Colin N A

AU - Kimber, Charlotte

AU - Tavendale, Roger

AU - Morris, Andrew D.

AU - McCarthy, Mark I.

AU - Walker, Mark

AU - Hitman, Graham

AU - Glaser, Benjamin

AU - Permutt, M. Alan

AU - Hattersley, Andrew T.

AU - Wareham, Nicholas J.

AU - Barroso, Inês

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Common variants in WFS1 confer risk of type 2 diabetes

Abstract

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