TY - JOUR
T1 - Common variants in WFS1 confer risk of type 2 diabetes
AU - Sandhu, Manjinder S.
AU - Weedon, Michael N.
AU - Fawcett, Katherine A.
AU - Wasson, Jon
AU - Debenham, Sally L.
AU - Daly, Allan
AU - Lango, Hana
AU - Frayling, Timothy M.
AU - Neumann, Rosalind J.
AU - Sherva, Richard
AU - Blech, Ilana
AU - Pharoah, Paul D.
AU - Palmer, Colin N A
AU - Kimber, Charlotte
AU - Tavendale, Roger
AU - Morris, Andrew D.
AU - McCarthy, Mark I.
AU - Walker, Mark
AU - Hitman, Graham
AU - Glaser, Benjamin
AU - Permutt, M. Alan
AU - Hattersley, Andrew T.
AU - Wareham, Nicholas J.
AU - Barroso, Inês
PY - 2007/8/1
Y1 - 2007/8/1
N2 - We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.
AB - We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.
UR - https://www.scopus.com/pages/publications/34547536393
U2 - 10.1038/ng2067
DO - 10.1038/ng2067
M3 - Article
C2 - 17603484
AN - SCOPUS:34547536393
SN - 1061-4036
VL - 39
SP - 951
EP - 953
JO - Nature Genetics
JF - Nature Genetics
IS - 8
ER -