Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time

Lorna Houlihan; Gail Davies; Albert Tenesa; Sarah E. Harris; Michelle Luciano; Alan J. Gow; Kevin McGhee; David C. Liewald; David J. Porteous; John Starr; G. D. Lowe; P M Visscher; Ian Deary

doi:10.1016/j.ajhg.2010.02.016

Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time

Lorna Houlihan, Gail Davies, Albert Tenesa, Sarah E. Harris, Michelle Luciano, Alan J. Gow, Kevin McGhee, David C. Liewald, David J. Porteous, John Starr, G. D. Lowe, P M Visscher, Ian Deary

Research output: Contribution to journal › Article › peer-review

Abstract

Activated partial thromboplastin time (aPTF) is associated with risk of thrombosis and coagulation disorders. We conducted a genome-wide association study for aPTT and identified significant associations with SNPs in three coagulation cascade genes, F12 (rs2731672, combined p = 2.16 x 10(-30)), KNG1 (rs710446, combined p = 9.52 x 10(-22)), and HRG (rs9898, combined p = 1.34 x 10(-11)). These three SNPs explain similar to 18% of phenotypic variance in aPTT in the Lothian Birth Cohorts.

Original language	English
Pages (from-to)	626-631
Number of pages	6
Journal	American Journal of Human Genetics
Volume	86
Issue number	4
DOIs	https://doi.org/10.1016/j.ajhg.2010.02.016
Publication status	Published - Apr 2010

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MRC Centre for Cognitive Ageing and Cognitive Epidemiology
Deary, I., Holmes, M., Logie, R., McCulloch, J., Porteous, D., Roberts, N., Seckl, J., Starr, J. & Wardlaw, J.
MRC
1/09/08 → 31/08/13
Project: Research
A genome wide association study of non pathological cognitive ageing
Deary, I., Porteous, D. & Tenesa, A.
BBSRC
1/09/08 → 31/08/10
Project: Research
The Disconnected Mind [Phase 1]: Main Grant
McCulloch, J., Bastin, M., Deary, I., Horsburgh, K., Morris, R., Starr, J. & Wardlaw, J.
UK-based charities
1/07/07 → 31/12/11
Project: Research

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Houlihan, L., Davies, G., Tenesa, A., Harris, S. E., Luciano, M., Gow, A. J., McGhee, K., Liewald, D. C., Porteous, D. J., Starr, J., Lowe, G. D., Visscher, P. M., & Deary, I. (2010). Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time. American Journal of Human Genetics, 86(4), 626-631. https://doi.org/10.1016/j.ajhg.2010.02.016

Houlihan, Lorna ; Davies, Gail ; Tenesa, Albert ; Harris, Sarah E. ; Luciano, Michelle ; Gow, Alan J. ; McGhee, Kevin ; Liewald, David C. ; Porteous, David J. ; Starr, John ; Lowe, G. D. ; Visscher, P M ; Deary, Ian. / Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time. In: American Journal of Human Genetics. 2010 ; Vol. 86, No. 4. pp. 626-631.

@article{3ba51cd07d9a47e98d17fd8390bc494e,

title = "Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time",

abstract = "Activated partial thromboplastin time (aPTF) is associated with risk of thrombosis and coagulation disorders. We conducted a genome-wide association study for aPTT and identified significant associations with SNPs in three coagulation cascade genes, F12 (rs2731672, combined p = 2.16 x 10(-30)), KNG1 (rs710446, combined p = 9.52 x 10(-22)), and HRG (rs9898, combined p = 1.34 x 10(-11)). These three SNPs explain similar to 18% of phenotypic variance in aPTT in the Lothian Birth Cohorts.",

author = "Lorna Houlihan and Gail Davies and Albert Tenesa and Harris, {Sarah E.} and Michelle Luciano and Gow, {Alan J.} and Kevin McGhee and Liewald, {David C.} and Porteous, {David J.} and John Starr and Lowe, {G. D.} and Visscher, {P M} and Ian Deary",

year = "2010",

month = apr,

doi = "10.1016/j.ajhg.2010.02.016",

language = "English",

volume = "86",

pages = "626--631",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "4",

}

Houlihan, L, Davies, G , Tenesa, A , Harris, SE , Luciano, M, Gow, AJ, McGhee, K, Liewald, DC, Porteous, DJ, Starr, J, Lowe, GD, Visscher, PM & Deary, I 2010, 'Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time', American Journal of Human Genetics, vol. 86, no. 4, pp. 626-631. https://doi.org/10.1016/j.ajhg.2010.02.016

Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time. / Houlihan, Lorna; Davies, Gail ; Tenesa, Albert ; Harris, Sarah E.; Luciano, Michelle; Gow, Alan J.; McGhee, Kevin; Liewald, David C.; Porteous, David J.; Starr, John; Lowe, G. D.; Visscher, P M; Deary, Ian.

In: American Journal of Human Genetics, Vol. 86, No. 4, 04.2010, p. 626-631.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time

AU - Houlihan, Lorna

AU - Davies, Gail

AU - Tenesa, Albert

AU - Harris, Sarah E.

AU - Luciano, Michelle

AU - Gow, Alan J.

AU - McGhee, Kevin

AU - Liewald, David C.

AU - Porteous, David J.

AU - Starr, John

AU - Lowe, G. D.

AU - Visscher, P M

AU - Deary, Ian

PY - 2010/4

Y1 - 2010/4

N2 - Activated partial thromboplastin time (aPTF) is associated with risk of thrombosis and coagulation disorders. We conducted a genome-wide association study for aPTT and identified significant associations with SNPs in three coagulation cascade genes, F12 (rs2731672, combined p = 2.16 x 10(-30)), KNG1 (rs710446, combined p = 9.52 x 10(-22)), and HRG (rs9898, combined p = 1.34 x 10(-11)). These three SNPs explain similar to 18% of phenotypic variance in aPTT in the Lothian Birth Cohorts.

AB - Activated partial thromboplastin time (aPTF) is associated with risk of thrombosis and coagulation disorders. We conducted a genome-wide association study for aPTT and identified significant associations with SNPs in three coagulation cascade genes, F12 (rs2731672, combined p = 2.16 x 10(-30)), KNG1 (rs710446, combined p = 9.52 x 10(-22)), and HRG (rs9898, combined p = 1.34 x 10(-11)). These three SNPs explain similar to 18% of phenotypic variance in aPTT in the Lothian Birth Cohorts.

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U2 - 10.1016/j.ajhg.2010.02.016

DO - 10.1016/j.ajhg.2010.02.016

M3 - Article

VL - 86

SP - 626

EP - 631

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

SN - 0002-9297

IS - 4

ER -

Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time

Abstract

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MRC Centre for Cognitive Ageing and Cognitive Epidemiology

A genome wide association study of non pathological cognitive ageing

The Disconnected Mind [Phase 1]: Main Grant

Cite this