Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk

P. Broderick, D. Chubb, D. C. Johnson, N. Weinhold, A. Forsti, A. Lloyd, B. Olver, Y. P. Ma, S. E. Dobbins, B. A. Walker, F. E. Davies, W. A. Gregory, J. A. Child, F. M. Ross, G. H. Jackson, K. Neben, A. Jauch, P. Hoffmann, T. W. Muhleisen, M. M. NothenS. Moebus, I. P. Tomlinson, H. Goldschmidt, K. Hemminki, G. J. Morgan, R. S. Houlston

Research output: Contribution to journalLetterpeer-review

Abstract

To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10−9) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10−15). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 × 10−7). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.
Original languageEnglish
Pages (from-to)58-61
JournalNature Genetics
Volume44
Issue number1
DOIs
Publication statusPublished - 2012

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