Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon

Samuel Wanji, Nicholas Tendongfor, Theolbald Nji, Mathias Esum, Julious N Che, Armand Nkwescheu, Fifen Alassa, Geremy Kamnang, Peter A Enyong, Mark J Taylor, Achim Hoerauf, David W Taylor

Research output: Contribution to journalArticlepeer-review

Abstract

Severe side effects following ivermectin treatment of onchocerciasis in areas of co-endemicity with loaisis have been an impediment for the work of the African Programme for Onchocerciasis Control (APOC) in forested regions of several countries. Doxycycline has been shown to be effective in the treatment of onchocerciasis and has the added advantages of killing adult Onchocerca volvulus but neither adult Loa loa nor their microfilariae. This drug therefore offers great potential for the treatment of onchocerciasis in areas of co-endemicity with loiasis. The limitation of use of this drug is the duration of treatment that may pose a potential problem with therapeutic coverage and compliance with treatment. To benefit from the advantages that doxycycline offers in the treatment of onchocerciasis, it will be necessary to establish an effective distribution system that can access remote communities. This study assessed the feasibility of a large-scale distribution of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis using a community-directed approach.
Original languageEnglish
Article number39
JournalParasites and Vectors
Volume2
Issue number1
DOIs
Publication statusPublished - 2009

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