Comparative Analysis of Bivalent Domains in Mammalian Embryonic Stem Cells

Anna Mantsoki, Anagha Joshi

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review


Bivalent promoters are defined by the presence of both activating (H3K4me3) and repressive (H3K27me3) chromatin marks. In this paper, we first identified high confidence bivalent promoters in murine ES cells integrating data across eight studies using two methods; peak-based and cutoff-based. We showed that peak-based method is more reliable as promoters are more enriched for developmental regulators than the cutoff-based method. We further identified bivalent promoters in human and pig using the peak-based method to show that the bivalent promoters conserved across species were highly enriched for embryonic developmental processes
Original languageEnglish
Title of host publicationBioinformatics and Biomedical Engineering
PublisherSpringer International Publishing
Publication statusPublished - 15 Apr 2015

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