Comparative analysis of normal prion protein expression on human, rodent, and ruminant blood cells by using a panel of prion antibodies

G Robin Barclay, Fiona Houston, Sue I Halliday, Christine F Farquhar, Marc L Turner

Research output: Contribution to journalArticlepeer-review

Abstract

It is not known whether variant CJD can be transmitted within the human population by blood transfusion. The expression of normal cellular prion protein (PrPC) by different blood cell types may permit selective uptake and dissemination of infectivity.
Original languageEnglish
Pages (from-to)517-26
Number of pages10
JournalTransfusion
Volume42
Issue number5
DOIs
Publication statusPublished - May 2002

Keywords

  • Animals
  • Antibodies, Monoclonal
  • Antibody Specificity
  • Blood Cells
  • Cattle
  • Cricetinae
  • Cross Reactions
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Flow Cytometry
  • Humans
  • Male
  • Mesocricetus
  • Mice
  • Mice, Inbred C57BL
  • Organ Specificity
  • PrPC Proteins
  • Rabbits
  • Sheep
  • Species Specificity

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