Comparative analysis of normal prion protein expression on human, rodent, and ruminant blood cells by using a panel of prion antibodies

G Robin Barclay; Fiona Houston; Sue I Halliday; Christine F Farquhar; Marc L Turner

doi:10.1046/j.1537-2995.2002.00095.x

Comparative analysis of normal prion protein expression on human, rodent, and ruminant blood cells by using a panel of prion antibodies

G Robin Barclay, Fiona Houston, Sue I Halliday, Christine F Farquhar, Marc L Turner

Research output: Contribution to journal › Article › peer-review

Abstract

It is not known whether variant CJD can be transmitted within the human population by blood transfusion. The expression of normal cellular prion protein (PrPC) by different blood cell types may permit selective uptake and dissemination of infectivity.

Original language	English
Pages (from-to)	517-26
Number of pages	10
Journal	Transfusion
Volume	42
Issue number	5
DOIs	https://doi.org/10.1046/j.1537-2995.2002.00095.x
Publication status	Published - May 2002

Keywords / Materials (for Non-textual outputs)

Animals
Antibodies, Monoclonal
Antibody Specificity
Blood Cells
Cattle
Cricetinae
Cross Reactions
Enzyme-Linked Immunosorbent Assay
Female
Flow Cytometry
Humans
Male
Mesocricetus
Mice
Mice, Inbred C57BL
Organ Specificity
PrPC Proteins
Rabbits
Sheep
Species Specificity

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10.1046/j.1537-2995.2002.00095.x

http://onlinelibrary.wiley.com/doi/10.1046/j.1537-2995.2002.00095.x/abstract

Cite this

@article{d55c887ddaf3406b9ed210f827f7759b,

title = "Comparative analysis of normal prion protein expression on human, rodent, and ruminant blood cells by using a panel of prion antibodies",

abstract = "It is not known whether variant CJD can be transmitted within the human population by blood transfusion. The expression of normal cellular prion protein (PrPC) by different blood cell types may permit selective uptake and dissemination of infectivity.",

keywords = "Animals, Antibodies, Monoclonal, Antibody Specificity, Blood Cells, Cattle, Cricetinae, Cross Reactions, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Humans, Male, Mesocricetus, Mice, Mice, Inbred C57BL, Organ Specificity, PrPC Proteins, Rabbits, Sheep, Species Specificity",

author = "Barclay, \{G Robin\} and Fiona Houston and Halliday, \{Sue I\} and Farquhar, \{Christine F\} and Turner, \{Marc L\}",

year = "2002",

month = may,

doi = "10.1046/j.1537-2995.2002.00095.x",

language = "English",

volume = "42",

pages = "517--26",

journal = "Transfusion",

issn = "0041-1132",

publisher = "Wiley",

number = "5",

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T1 - Comparative analysis of normal prion protein expression on human, rodent, and ruminant blood cells by using a panel of prion antibodies

AU - Barclay, G Robin

AU - Houston, Fiona

AU - Halliday, Sue I

AU - Farquhar, Christine F

AU - Turner, Marc L

PY - 2002/5

Y1 - 2002/5

N2 - It is not known whether variant CJD can be transmitted within the human population by blood transfusion. The expression of normal cellular prion protein (PrPC) by different blood cell types may permit selective uptake and dissemination of infectivity.

AB - It is not known whether variant CJD can be transmitted within the human population by blood transfusion. The expression of normal cellular prion protein (PrPC) by different blood cell types may permit selective uptake and dissemination of infectivity.

KW - Animals

KW - Antibodies, Monoclonal

KW - Antibody Specificity

KW - Blood Cells

KW - Cattle

KW - Cricetinae

KW - Cross Reactions

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Male

KW - Mesocricetus

KW - Mice

KW - Mice, Inbred C57BL

KW - Organ Specificity

KW - PrPC Proteins

KW - Rabbits

KW - Sheep

KW - Species Specificity

U2 - 10.1046/j.1537-2995.2002.00095.x

DO - 10.1046/j.1537-2995.2002.00095.x

M3 - Article

C2 - 12084159

SN - 0041-1132

VL - 42

SP - 517

EP - 526

JO - Transfusion

JF - Transfusion

IS - 5

ER -

Comparative analysis of normal prion protein expression on human, rodent, and ruminant blood cells by using a panel of prion antibodies

Abstract

Keywords / Materials (for Non-textual outputs)

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