Comparative evidence for a link between Peyer's patch development and susceptibility to transmissible spongiform encephalopathies

Suzanne G St Rose; Nora Hunter; Louise Matthews; James D Foster; Margo E Chase-Topping; Loeske E B Kruuk; Darren J Shaw; Susan M Rhind; Robert G Will; Mark E J Woolhouse

doi:10.1186/1471-2334-6-5

Comparative evidence for a link between Peyer's patch development and susceptibility to transmissible spongiform encephalopathies

Suzanne G St Rose, Nora Hunter, Louise Matthews, James D Foster, Margo E Chase-Topping, Loeske E B Kruuk, Darren J Shaw, Susan M Rhind, Robert G Will, Mark E J Woolhouse

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Abstract

Epidemiological analyses indicate that the age distribution of natural cases of transmissible spongiform encephalopathies (TSEs) reflect age-related risk of infection, however, the underlying mechanisms remain poorly understood. Using a comparative approach, we tested the hypothesis that, there is a significant correlation between risk of infection for scrapie, bovine spongiform encephalopathy (BSE) and variant CJD (vCJD), and the development of lymphoid tissue in the gut.

Original language	English
Pages (from-to)	5
Journal	BMC Infectious Diseases
Volume	6
DOIs	https://doi.org/10.1186/1471-2334-6-5
Publication status	Published - 2006

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title = "Comparative evidence for a link between Peyer's patch development and susceptibility to transmissible spongiform encephalopathies",

abstract = "Epidemiological analyses indicate that the age distribution of natural cases of transmissible spongiform encephalopathies (TSEs) reflect age-related risk of infection, however, the underlying mechanisms remain poorly understood. Using a comparative approach, we tested the hypothesis that, there is a significant correlation between risk of infection for scrapie, bovine spongiform encephalopathy (BSE) and variant CJD (vCJD), and the development of lymphoid tissue in the gut.",

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AU - St Rose, Suzanne G

AU - Hunter, Nora

AU - Matthews, Louise

AU - Foster, James D

AU - Chase-Topping, Margo E

AU - Kruuk, Loeske E B

AU - Shaw, Darren J

AU - Rhind, Susan M

AU - Will, Robert G

AU - Woolhouse, Mark E J

PY - 2006

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N2 - Epidemiological analyses indicate that the age distribution of natural cases of transmissible spongiform encephalopathies (TSEs) reflect age-related risk of infection, however, the underlying mechanisms remain poorly understood. Using a comparative approach, we tested the hypothesis that, there is a significant correlation between risk of infection for scrapie, bovine spongiform encephalopathy (BSE) and variant CJD (vCJD), and the development of lymphoid tissue in the gut.

AB - Epidemiological analyses indicate that the age distribution of natural cases of transmissible spongiform encephalopathies (TSEs) reflect age-related risk of infection, however, the underlying mechanisms remain poorly understood. Using a comparative approach, we tested the hypothesis that, there is a significant correlation between risk of infection for scrapie, bovine spongiform encephalopathy (BSE) and variant CJD (vCJD), and the development of lymphoid tissue in the gut.

U2 - 10.1186/1471-2334-6-5

DO - 10.1186/1471-2334-6-5

M3 - Article

C2 - 16405727

SN - 1471-2334

VL - 6

SP - 5

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

ER -

Comparative evidence for a link between Peyer's patch development and susceptibility to transmissible spongiform encephalopathies

Abstract

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