Comparative expression profiling of Leishmania: modulation in gene expression between species and in different host genetic backgrounds

Daniel P Depledge, Krystal J Evans, Alasdair C Ivens, Naveed Aziz, Asher Maroof, Paul M Kaye, Deborah F Smith

Research output: Contribution to journalArticlepeer-review

Abstract

Genome sequencing of Leishmania species that give rise to a range of disease phenotypes in the host has revealed highly conserved gene content and synteny across the genus. Only a small number of genes are differentially distributed between the three species sequenced to date, L. major, L. infantum and L. braziliensis. It is not yet known how many of these genes are expressed in the disease-promoting intracellular amastigotes of these species or whether genes conserved between the species are differentially expressed in the host.
Original languageEnglish
Article numbere476
JournalPLoS Neglected Tropical Diseases
Volume3
Issue number7
DOIs
Publication statusPublished - 2009

Keywords

  • Gene Expression Profiling
  • Animals
  • Leishmania infantum
  • Oligonucleotide Array Sequence Analysis
  • Leishmania braziliensis
  • Host-Parasite Interactions
  • Mice, Inbred C57BL
  • Mice
  • Mice, Inbred BALB C
  • Leishmania major
  • Stress, Physiological
  • Mice, Knockout

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