@article{f56db2da13304fefab0eb91aa7989879,
title = "Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways",
abstract = "We have determined the complete genome sequences of a host-promiscuous Salmonella enterica serovar Enteritidis PT4 isolate P125109 and a chicken-restricted Salmonella enterica serovar Gallinarum isolate 287/91. Genome comparisons between these and other Salmonella isolates indicate that S. Gallinarum 287/ 91 is a recently evolved descendent of S. Enteritidis. Significantly, the genome of S. Gallinarum has undergone extensive degradation through deletion and pseudogene formation. Comparison of the pseudogenes in S. Gallinarum with those identified previously in other host-adapted bacteria reveals the loss of many common functional traits and provides insights into possible mechanisms of host and tissue adaptation. We propose that experimental analysis in chickens and mice of S. Enteritidis-harboring mutations in functional homologs of the pseudogenes present in S. Gallinarum could provide an experimentally tractable route toward unraveling the genetic basis of host adaptation in S. enterica.",
keywords = "enterica serovar typhimurium escherichia-coli pathogenicity islands sequence-analysis identification genes gallinarum infection virulence dna",
author = "N.R. Thomson and D.J. Clayton and D. Windhorst and G. Vernikos and S. Davidson and C. Churcher and M.A. Quail and Mark Stevens and M.A. Jones and M. Watson and A. Barron and A. Layton and D. Pickard and R.A. Kingsley and A. Bignell and L. Clark and B. Harris and D. Ormond and Z. Abdellah and K. Brooks and I. Cherevach and T. Chillingworth and J. Woodward and H. Norberczak and A. Lord and C. Arrowsmith and K. Jagels and S. Moule and K. Mungall and M. Sanders and S. Whitehead and J.A. Chabalgoity and D. Maskell and T. Humphrey and M. Roberts and P.A. Barrow and G. Dougan and J. Parkhill",
note = "WOS:000259700800009 Times Cited: 54 Thomson, Nicholas R. Clayton, Debra J. Windhorst, Daniel Vernikos, Georgios Davidson, Susanne Churcher, Carol Quail, Michael A. Stevens, Mark Jones, Michael A. Watson, Michael Barron, Andy Layton, Abigail Pickard, Derek Kingsley, Robert A. Bignell, Alex Clark, Louise Harris, Barbara Ormond, Doug Abdellah, Zahra Brooks, Karen Cherevach, Inna Chillingworth, Tracey Woodward, John Norberczak, Halina Lord, Angela Arrowsmith, Claire Jagels, Kay Moule, Sharon Mungall, Karen Sanders, Mandy Whitehead, Sally Chabalgoity, Jose A. Maskell, Duncan Humphrey, Tom Roberts, Mark Barrow, Paul A. Dougan, Gordon Parkhill, Julian",
year = "2008",
doi = "10.1101/gr.077404.108",
language = "Undefined/Unknown",
volume = "18",
pages = "1624--1637",
journal = "Genome Research",
issn = "1088-9051",
publisher = "COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT",
number = "10",
}