Comparative genomic analysis of genes encoding translation elongation factor 1B(alpha) in human and mouse shows EEF1B1 to be a recent retrotransposition event

D M Chambers, G A Rouleau, C M Abbott

Research output: Contribution to journalArticlepeer-review

Abstract

We have characterized genomic loci encoding translation elongation factor 1B(alpha) (eEF1B(alpha)) in mice and humans. Mice have a single structural locus (named Eef1b2) spanning six exons, which is ubiquitously expressed and maps close to Casp8 on mouse chromosome 1, and a processed pseudogene. Humans have a single intron-containing locus, EEF1B2, which maps to 2q33, and an intronless paralogue expressed only in brain and muscle (EEF1B3). Another locus described previously, EEF1B1, is actually a processed pseudogene on chromosome 15 corresponding to an alternative splice form of EEF1B2. Our study illustrates the value of comparative mapping in distinguishing between processed pseudogenes and intronless paralogues.
Original languageEnglish
Pages (from-to)145-8
Number of pages4
JournalGenomics
Volume77
Issue number3
DOIs
Publication statusPublished - 2001

Keywords

  • Alternative Splicing
  • Animals
  • Chromosome Mapping
  • Chromosomes, Human, Pair 15
  • Chromosomes, Human, Pair 2
  • Exons
  • Expressed Sequence Tags
  • Humans
  • Introns
  • Mice
  • Peptide Elongation Factor 1
  • Pseudogenes

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