Comparative genomics of Listeria species

P Glaser, L Frangeul, C Buchrieser, C Rusniok, A Amend, F Baquero, P Berche, H Bloecker, P Brandt, T. Chakraborty, A Charbit, F Chetouani, E Couvé, A de Daruvar, P Dehoux, E Domann, G Dominguez-Bernal, E Duchaud, L Durant, O DussurgetK-D Entian, H Fsihi, F García-del Portillo, P Garrido, L Gautier, Werner Goebel, N Gomez-Lopez, T Hain, J Hauf, D Jackson, L-M Jones, U Kaerst, J. Kreft, M Kuhn, F Kunst, G Kurapkat, E Madueño, A Maitournam, J Mata Vicente, E Ng, H Nedjari, G Nordsiek, S Novella, B de Pablos, JC Pérez-Diaz , R Purcell, B Remmel, M Rose, T Schlueter, N Simoes, A Tierrez, Jose A Vazquez-Boland, H Voss, J Wehland, P Cossart

Research output: Contribution to journalArticlepeer-review

Abstract

Listeria monocytogenes is a food-borne pathogen with a high mortality rate that has also emerged as a paradigm for intracellular parasitism. We present and compare the genome sequences of L. monocytogenes (2,944,528 base pairs) and a nonpathogenic species, L. innocua (3,011,209 base pairs). We found a large number of predicted genes encoding surface and secreted proteins, transporters, and transcriptional regulators, consistent with the ability of both species to adapt to diverse environments. The presence of 270 L. monocytogenes and 149 L. innocua strain-specific genes (clustered in 100 and 63 islets, respectively) suggests that virulence in Listeria results from multiple gene acquisition and deletion events.
Original languageEnglish
Pages (from-to)849-52
Number of pages4
JournalScience
Volume294
Issue number5543
DOIs
Publication statusPublished - 26 Oct 2001

Keywords

  • Adaptation, Physiological
  • Amino Acid Motifs
  • Bacillus subtilis/genetics
  • Bacterial Proteins/chemistry
  • Bacterial Proteins/genetics
  • Bacterial Proteins/physiology
  • Base Composition
  • Carrier Proteins/chemistry
  • Carrier Proteins/genetics
  • Chromosomes, Bacterial/genetics
  • DNA, Bacterial/chemistry
  • DNA, Bacterial/genetics
  • Gene Transfer, Horizontal
  • Genes, Bacterial
  • Genome, Bacterial
  • Genomics
  • Listeria/chemistry
  • Listeria/genetics
  • Listeria/physiology
  • Listeria monocytogenes/chemistry
  • Listeria monocytogenes/genetics
  • Listeria monocytogenes/pathogenicity
  • Listeria monocytogenes/physiology
  • Membrane Proteins/chemistry
  • Membrane Proteins/genetics
  • Sequence Analysis, DNA
  • Staphylococcus aureus/genetics
  • Transcription Factors/chemistry
  • Transcription Factors/genetics
  • Virulence/genetics

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