Comparative genomics of trypanosomatid parasitic protozoa

NM El-Sayed*, PJ Myler, G Blandin, M Berriman, J Crabtree, G Aggarwal, E Caler, H Renauld, EA Worthey, C Hertz-Fowler, E Ghedin, C Peacock, DC Bartholomeu, BJ Haas, AN Tran, Jennifer R Wortman, UCM Alsmark, S Angiuoli, A Anupama, J BadgerF Bringaud, E Cadag, JM Carlton, GC Cerqueira, T Creasy, AL Delcher, A Djikeng, TM Embley, C Hauser, AC Ivens, SK Kummerfeld, JB Pereira-Leal, D Nilsson, J Peterson, SL Salzberg, J Shallom, JC Silva, J Sundaram, S Westenberger, O White, SE Metville, JE Donelson, B Andersson, KD Stuart, N Hall

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology,. revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many, species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that-along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.

Original languageEnglish
Pages (from-to)404-409
Number of pages6
JournalScience
Volume309
Issue number5733
DOIs
Publication statusPublished - 15 Jul 2005

Keywords

  • HOST-CELL INVASION
  • LEISHMANIA-MAJOR
  • MOLECULAR PHYLOGENY
  • BRUCEI
  • CRUZI
  • GENE
  • TRANSCRIPTION
  • EVOLUTION
  • PROTEIN
  • LIFE

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