Comparative mapping of mouse chromosome 2 and human chromosome 9q: the genes for gelsolin and dopamine beta-hydroxylase map to mouse chromosome 2

A Pilz, H Moseley, J Peters, C Abbott

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The mapping of human chromosome 9 (HSA9) and mouse chromosome 2 (MMU2) has revealed a conserved syntenic region between the distal end of the long arm of chromosome 9 and proximal mouse chromosome 2. Two genes that map to human chromosome 9q34, gelsolin (GSN) and dopamine beta-hydroxylase (DBH), have not previously been located in the mouse. We have used an interspecific backcross to map each of these genes, by Southern blot analysis, to mouse chromosome 2. Gelsolin (Gsn) is tightly linked to the gene for complement component C5 (Hc), and dopamine beta-hydroxylase (Dbh) is just proximal to the Abelson leukemia virus oncogene (Abl) and alpha-spectrin 2 (Spna-2). The loci for gelsolin and dopamine beta-hydroxylase therefore form part of the conserved synteny between HSA9q and MMU2.
Original languageEnglish
Pages (from-to)715-9
Number of pages5
JournalGenomics
Volume12
Issue number4
Publication statusPublished - 1992

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Calcium-Binding Proteins
  • Chromosome Mapping
  • Chromosomes, Human, Pair 9
  • DNA
  • Dopamine beta-Hydroxylase
  • Female
  • Gelsolin
  • Genetic Linkage
  • Humans
  • Male
  • Mice
  • Microfilament Proteins
  • Muridae
  • Species Specificity

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