Comparative MHC nomenclature: Report from the ISAG/IUIS-VIC committee 2018

Keith T. Ballingall, Ronald E. Bontrop, Shirley A. Ellis, Unni Grimholt, John A. Hammond, Chak-sum Ho, Jim Kaufman, Lorna J. Kennedy, Giuseppe Maccari, Donald Miller, James Robinson, Steven G. E. Marsh

Research output: Contribution to journalArticlepeer-review

Abstract

Significant progress has been made over the last decade in defining major histocompatibility complex (MHC) diversity at the nucleotide, allele, haplotype, diplotype, and population levels in many non-human species. Much of this progress has been driven by the increased availability and reduced costs associated with nucleotide sequencing technologies. This report provides an update on the activities of the comparative MHC nomenclature committee which is a standing committee of both the International Society for Animal Genetics (ISAG) and the International Union of Immunological Societies (IUIS) where it operates under the umbrella of the Veterinary Immunology Committee (VIC). A previous report from this committee in 2006 defined the role of the committee in providing guidance in the development of a standardized nomenclature for genes and alleles at MHC loci in non-human species. It described the establishment of the Immuno Polymorphism Database, IPD-MHC, which continues to provide public access to high quality MHC sequence data across a range of species. In this report, guidelines for the continued development of a universal MHC nomenclature framework are described, summarizing the continued development of each species section within the IPD-MHC project.
Original languageEnglish
Pages (from-to)625-632
JournalImmunogenetics
Volume70
Issue number10
DOIs
Publication statusPublished - 1 Nov 2018

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