Comparing clinical perimetry and population receptive field measures in patients with choroideremia

Edward H. Silson, Tomas S. Aleman, Aimee Willett, Leona W. Serrano, Denise J. Pearson, Andreas M. Rauschecker, Albert M. Maguire, Chris I. Baker, Jean Bennett, Manzar Ashtari*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE. Choroideremia (CHM) is an X-linked recessive form of hereditary retinal degeneration, which, at advanced stages, leaves only small central islands of preserved retinal tissue. Unlike many other retinal diseases, the spared tissue in CHM supports excellent central vision and stable fixation. Such spared topography in CHM presents an ideal platform to explore the relationship between preserved central retinal structure and the retinotopic organization of visual cortex by using functional magnetic resonance imaging (fMRI).

METHODS. fMRI was conducted in four participants with CHM and four healthy control participants while they viewed drifting contrast pattern stimuli monocularly. A single similar to 3-minute fMRI run was collected for each eye separately. fMRI data were analyzed using the population receptive field (pRF) modeling approach. Participants also underwent ophthalmic evaluations of visual acuity and static automatic perimetry.

RESULTS. The spatial distribution and strength of pRF estimates correlated positively and significantly with clinical outcome measures in most participants with CHM. Importantly, the positive relationship between clinical and pRF measurements increased with increasing disease progression. A less consistent relationship was observed for control participants.

CONCLUSIONS. Although reflecting only a small sample size, clinical evaluations of visual function in participants with CHM were well characterized by the spatial distribution and strength of pRF estimates by using a single similar to 3-minute fMRI experiment. fMRI data analyzed with pRF modeling may be an efficient and objective outcome measure to complement current ophthalmic evaluations. Specifically, pRF modeling may be a feasible approach for evaluating the impact of interventions to restore visual function.

Original languageEnglish
Pages (from-to)3249-3258
Number of pages10
JournalInvestigative Ophthalmology & Visual Science
Volume59
Issue number8
Early online date31 Jul 2018
DOIs
Publication statusPublished - Jul 2018

Keywords

  • choroideremia
  • retinotopy
  • fMRI
  • population receptive fields

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