Comparing personalised brain-based and genetic risk scores for Major Depressive Disorder in large population samples of adults and adolescents

Gladi Thng; Xueyi Shen; Aleks Stolicyn; Mathew A. Harris; Mark J. Adams; Miruna C. Barbu; Alex S. F. Kwong; Sophia Frangou; Stephen M. Lawrie; Andrew M. Mcintosh; Liana Romaniuk; Heather C. Whalley

doi:10.1192/j.eurpsy.2022.2301

Comparing personalised brain-based and genetic risk scores for Major Depressive Disorder in large population samples of adults and adolescents

Gladi Thng, Xueyi Shen, Aleks Stolicyn, Mathew A. Harris, Mark J. Adams, Miruna C. Barbu, Alex S. F. Kwong, Sophia Frangou, Stephen M. Lawrie, Andrew M. Mcintosh, Liana Romaniuk, Heather C. Whalley

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1-34
Journal	European Psychiatry
Early online date	28 Jul 2022
DOIs	https://doi.org/10.1192/j.eurpsy.2022.2301
Publication status	E-pub ahead of print - 28 Jul 2022

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Thng, G., Shen, X., Stolicyn, A., Harris, M. A., Adams, M. J., Barbu, M. C., Kwong, A. S. F., Frangou, S., Lawrie, S. M., Mcintosh, A. M., Romaniuk, L., & Whalley, H. C. (2022). Comparing personalised brain-based and genetic risk scores for Major Depressive Disorder in large population samples of adults and adolescents. European Psychiatry, 1-34. Advance online publication. https://doi.org/10.1192/j.eurpsy.2022.2301

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title = "Comparing personalised brain-based and genetic risk scores for Major Depressive Disorder in large population samples of adults and adolescents",

author = "Gladi Thng and Xueyi Shen and Aleks Stolicyn and Harris, {Mathew A.} and Adams, {Mark J.} and Barbu, {Miruna C.} and Kwong, {Alex S. F.} and Sophia Frangou and Lawrie, {Stephen M.} and Mcintosh, {Andrew M.} and Liana Romaniuk and Whalley, {Heather C.}",

note = "Funding Information: Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council [HR03006] and is currently supported by the Wellcome Trust (216767/Z/19/Z). Genotyping of the Generation Scotland samples was carried out by the Genetics Core Laboratory at the Edinburgh Clinical Research Facility, University of Edinburgh, Scotland and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award “STratifying Resilience and Depression Longitudinally” (STRADL) Reference 104036/Z/14/Z). Funding Information: A.M.M. previously received research grant support from The Sackler Trust, as well as speaker fees from Illumina and Janssen. No potential conflicts of interest are reported for the other authors. Funding Information: The RVI_func() function was developed at the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, supported by an NIH R01 EB015611 grant. We would like to thank all of the participants for their time and effort taking part in the studies, the research assistants, clinicians and technicians for their help in data collection, and Laura De Nooij, Rebecca Madden, and Claire Green for their help with the QC of the FreeSurfer data in GS-Imaging. Funding Information: Data used in the preparation of this article were also obtained from the Adolescent Brain Cognitive Development (ABCD) Study ( https://abcdstudy.org ), held in the NIMH Data Archive (NDA). This is a multisite, longitudinal study designed to recruit more than 10,000 children aged 9–10 and follow them over 10 years into early adulthood. The ABCD Study is supported by the National Institutes of Health and additional federal partners under award numbers U01DA041048, U01DA050989, U01DA051016, U01DA041022, U01DA051018, U01DA051037, U01DA050987, U01DA041174, U01DA041106, U01DA041117, U01DA041028, U01DA041134, U01DA050988, U01DA051039, U01DA041156, U01DA041025, U01DA041120, U01DA051038, U01DA041148, U01DA041093, U01DA041089, U24DA041123, U24DA041147. A full list of supporters is available at https://abcdstudy.org/federal-partners.html . A listing of participating sites and a complete listing of the study investigators can be found at https://abcdstudy.org/consortium_members/ . ABCD consortium investigators designed and implemented the study and/or provided data but did not necessarily participate in the analysis or writing of this report. This manuscript reflects the views of the authors and may not reflect the opinions or views of the NIH or ABCD consortium investigators. Publisher Copyright: {\textcopyright} ",

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doi = "10.1192/j.eurpsy.2022.2301",

language = "English",

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T1 - Comparing personalised brain-based and genetic risk scores for Major Depressive Disorder in large population samples of adults and adolescents

AU - Thng, Gladi

AU - Shen, Xueyi

AU - Stolicyn, Aleks

AU - Harris, Mathew A.

AU - Adams, Mark J.

AU - Barbu, Miruna C.

AU - Kwong, Alex S. F.

AU - Frangou, Sophia

AU - Lawrie, Stephen M.

AU - Mcintosh, Andrew M.

AU - Romaniuk, Liana

AU - Whalley, Heather C.

N1 - Funding Information: Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council [HR03006] and is currently supported by the Wellcome Trust (216767/Z/19/Z). Genotyping of the Generation Scotland samples was carried out by the Genetics Core Laboratory at the Edinburgh Clinical Research Facility, University of Edinburgh, Scotland and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award “STratifying Resilience and Depression Longitudinally” (STRADL) Reference 104036/Z/14/Z). Funding Information: A.M.M. previously received research grant support from The Sackler Trust, as well as speaker fees from Illumina and Janssen. No potential conflicts of interest are reported for the other authors. Funding Information: The RVI_func() function was developed at the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, supported by an NIH R01 EB015611 grant. We would like to thank all of the participants for their time and effort taking part in the studies, the research assistants, clinicians and technicians for their help in data collection, and Laura De Nooij, Rebecca Madden, and Claire Green for their help with the QC of the FreeSurfer data in GS-Imaging. Funding Information: Data used in the preparation of this article were also obtained from the Adolescent Brain Cognitive Development (ABCD) Study ( https://abcdstudy.org ), held in the NIMH Data Archive (NDA). This is a multisite, longitudinal study designed to recruit more than 10,000 children aged 9–10 and follow them over 10 years into early adulthood. The ABCD Study is supported by the National Institutes of Health and additional federal partners under award numbers U01DA041048, U01DA050989, U01DA051016, U01DA041022, U01DA051018, U01DA051037, U01DA050987, U01DA041174, U01DA041106, U01DA041117, U01DA041028, U01DA041134, U01DA050988, U01DA051039, U01DA041156, U01DA041025, U01DA041120, U01DA051038, U01DA041148, U01DA041093, U01DA041089, U24DA041123, U24DA041147. A full list of supporters is available at https://abcdstudy.org/federal-partners.html . A listing of participating sites and a complete listing of the study investigators can be found at https://abcdstudy.org/consortium_members/ . ABCD consortium investigators designed and implemented the study and/or provided data but did not necessarily participate in the analysis or writing of this report. This manuscript reflects the views of the authors and may not reflect the opinions or views of the NIH or ABCD consortium investigators. Publisher Copyright: ©

PY - 2022/7/28

Y1 - 2022/7/28

U2 - 10.1192/j.eurpsy.2022.2301

DO - 10.1192/j.eurpsy.2022.2301

M3 - Article

SN - 0924-9338

SP - 1

EP - 34

JO - European Psychiatry

JF - European Psychiatry

ER -

Comparing personalised brain-based and genetic risk scores for Major Depressive Disorder in large population samples of adults and adolescents

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