Comparison Between High Sensitivity Cardiac Troponin T and Cardiac Troponin I in a Large General Population Cohort

Paul Welsh, David Preiss, Anoop Shah, David McAllister, Andrew H. Briggs, Charles Boachie, Alex McConnachie, Caroline Hayward, Sandosh Padmanabhan, Claire Welsh, Mark Woodward, Archibald Campbell, David Porteous, Nicholas Mills, Naveed Sattar

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Abstract / Description of output

BACKGROUND: Few data compare cardiac troponin T
(cTnT) and cardiac troponin I (cTnI) in a general population.
We sought to evaluate the distribution and association
between cTnT, cTnI, and cardiovascular risk factors in a
large general population cohort.
METHODS: High-sensitivity cTnT and cTnI were measured
in serum from 19501 individuals in the Generation
Scotland Scottish Family Health Study. Associations
with cardiovascular risk factors were compared using ageand
sex-adjusted regression. Observed age- and sexstratified
99th centiles were compared with 99th centiles
for cTnT (men, 15.5 ng/L; women, 9.0 ng/L) and cTnI
(men, 34.2 ng/L; women, 15.6 ng/L) used in clinical
RESULTS: cTnT and cTnI concentrations were detectable
in 53.3% and 74.8% of participants, respectively, and
were modestly correlated in unadjusted analyses (R2
21.3%) and only weakly correlated after adjusting for age
and sex (R2 9.5%). Cardiovascular risk factors were
associated with both troponins, but in age- and sexadjusted
analyses, cTnI was more strongly associated
with age, male sex, body mass index, and systolic blood
pressure (P 0.0001 for all vs cTnT). cTnT was more
strongly associated with diabetes (P 0.0001 vs cTnI).
The observed 99th centiles were broadly consistent with
recommended 99th centiles in younger men and women.
After the age of 60 years, observed 99th centiles increased
substantially for cTnT, and beyond 70 years of age, the
99th centiles approximately doubled for both troponins.
CONCLUSIONS: In the general population, cTnT and
cTnI concentrations are weakly correlated and are differentially
associated with cardiovascular risk factors. The
99th centiles currently in use are broadly appropriate for
men and women up to but not beyond the age of 60
Original languageEnglish
Number of pages10
JournalClinical Chemistry
Issue number11
Publication statusPublished - 20 Aug 2018


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