TY - JOUR
T1 - Comparison of Associations with Different Macular Inner Retinal Thickness Parameters in a Large Cohort
T2 - The UK Biobank
AU - Khawaja, Anthony P.
AU - Chua, Sharon Y.L.
AU - Hysi, Pirro G.
AU - Georgoulas, Stelios
AU - Currant, Hannah
AU - Fitzgerald, Tomas W.
AU - Birney, Ewan
AU - Ko, Fang
AU - Yang, Qi
AU - Reisman, Charles
AU - Garway-Heath, David F.
AU - Hammond, Chris J.
AU - Khaw, Peng T.
AU - Foster, Paul
AU - Patel, Praveen
AU - Strouthidis, Nicholas
AU - UK Biobank Eye and Vision Consortium
AU - Atan, Denize
AU - Aslam, Tariq
AU - Barman, Sarah A.
AU - Barrett, Jenny H.
AU - Bishop, Paul
AU - Blows, Peter
AU - Bunce, Catey
AU - Carare, Roxana O.
AU - Chakravarthy, Usha
AU - Chan, Michelle
AU - Chua, Sharon Y.L.
AU - Crabb, David P.
AU - Cumberland, Philippa M.
AU - Day, Alexander
AU - Desai, Parul
AU - Dick, Andrew D.
AU - Egan, Cathy
AU - Ennis, Sarah
AU - Foster, Paul
AU - Fruttiger, Marcus
AU - Gallacher, John E.J.
AU - Gibson, Jane
AU - Gore, Dan
AU - Guggenheim, Jeremy A.
AU - Hardcastle, Alison
AU - Hogg, Ruth E.
AU - Keane, Pearse A.
AU - Lascaratos, Gerassimos
AU - Lotery, Andrew J.
AU - Mackie, Sarah
AU - Martin, Keith
AU - McGaughey, Michelle
AU - McGuinness, Bernadette
AU - McKay, Gareth J.
AU - McKibbin, Martin
AU - Moore, Tony
AU - Morgan, James E.
AU - Muthy, Zaynah A.
AU - Owen, Chris G.
AU - Patel, Praveen
AU - Paterson, Euan
AU - Peto, Tunde
AU - Petzold, Axel
AU - Rahi, Jugnoo S.
AU - Rudnikca, Alicja R.
AU - Self, Jay
AU - Sivaprasad, Sobha
AU - Steel, David
AU - Stratton, Irene
AU - Thomas, Dhanes
AU - Trucco, Emanuele
AU - Tufail, Adnan
AU - Vernon, Stephen A.
AU - Viswanathan, Ananth C.
AU - Williams, Cathy
AU - Williams, Katie
AU - Woodside, Jayne V.
AU - Yates, Max M.
AU - Yip, Jennifer
AU - Zheng, Yalin
A2 - Dhillon, Bal
A2 - Harding, Simon P.
A2 - Macgillivray, Tom
A2 - Mitry, Danny
A2 - O'Sullivan, Eoin
A2 - Sudlow, Cathie
A2 - Vitart, Veronique
N1 - Funding Information:
The UK Biobank (Appendix 1, available at www.aaojournal.org) was established by the Wellcome Trust medical charity; the Medical Research Council, Department of Health, Scottish Government; and the Northwest Regional Development Agency. It has also had funding from the Welsh Assembly Government, British Heart Foundation, and Diabetes United Kingdom. Dr. Foster is supported by the Richard Desmond Charitable Trust via Fight for Sight (1956), the Special Trustees of Moorfields Eye Hospital (ST 12 09), and the Department of Health and Social Care through the award made by the NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust (BRC2_009). The funding organizations had no role in the design or conduct of this research.
Publisher Copyright:
© 2019 American Academy of Ophthalmology
PY - 2019/8/21
Y1 - 2019/8/21
N2 - Purpose: To describe and compare associations with macular retinal nerve fiber layer (mRNFL), ganglion cell complex (GCC), and ganglion cell–inner plexiform layer (GCIPL) thicknesses in a large cohort. Design: Cross-sectional study. Participants: We included 42 044 participants in the UK Biobank. The mean age was 56 years. Methods: Spectral-domain OCT macular images were segmented and analyzed. Corneal-compensated intraocular pressure (IOPcc) was measured with the Ocular Response Analyzer (Reichert, Corp., Buffalo, NY). Multivariable linear regression was used to examine associations with mean mRNFL, GCC, and GCIPL thicknesses. Factors examined were age, sex, ethnicity, height, body mass index (BMI), smoking status, alcohol intake, Townsend deprivation index, education level, diabetes status, spherical equivalent, and IOPcc. Main Outcome Measures: Thicknesses of mRNFL, GCC, and GCIPL. Results: We identified several novel independent associations with thinner inner retinal thickness. Thinner inner retina was associated with alcohol intake (most significant for GCIPL: –0.46 μm for daily or almost daily intake compared with special occasion only or never [95% confidence interval (CI), 0.61–0.30]; P = 1.1×10–8), greater social deprivation (most significant for GCIPL: –0.28 μm for most deprived quartile compared with least deprived quartile [95% CI, –0.42 to –0.14]; P = 6.6×10–5), lower educational attainment (most significant for mRNFL: –0.36 μm for less than O level compared with degree level [95% CI, –0.45 to 0.26]; P = 2.3×10–14), and nonwhite ethnicity (most significant for mRNFL comparing blacks with whites: –1.65 μm [95% CI, –1.86 to –1.43]; P = 2.4×10–50). Corneal-compensated intraocular pressure was associated most significantly with GCIPL (–0.04 μm/mmHg [95% CI, –0.05 to –0.03]; P = 4.0×10–10) and was not associated significantly with mRNFL (0.00 μm/mmHg [95% CI, –0.01 to 0.01]; P = 0.77). The variables examined explained a greater proportion of the variance of GCIPL (11%) than GCC (6%) or mRNFL (7%). Conclusions: The novel associations we identified may be important to consider when using inner retinal parameters as a diagnostic tool. Associations generally were strongest with GCIPL, particularly for IOP. This suggests that GCIPL may be the superior inner retinal biomarker for macular pathophysiologic processes and especially for glaucoma.
AB - Purpose: To describe and compare associations with macular retinal nerve fiber layer (mRNFL), ganglion cell complex (GCC), and ganglion cell–inner plexiform layer (GCIPL) thicknesses in a large cohort. Design: Cross-sectional study. Participants: We included 42 044 participants in the UK Biobank. The mean age was 56 years. Methods: Spectral-domain OCT macular images were segmented and analyzed. Corneal-compensated intraocular pressure (IOPcc) was measured with the Ocular Response Analyzer (Reichert, Corp., Buffalo, NY). Multivariable linear regression was used to examine associations with mean mRNFL, GCC, and GCIPL thicknesses. Factors examined were age, sex, ethnicity, height, body mass index (BMI), smoking status, alcohol intake, Townsend deprivation index, education level, diabetes status, spherical equivalent, and IOPcc. Main Outcome Measures: Thicknesses of mRNFL, GCC, and GCIPL. Results: We identified several novel independent associations with thinner inner retinal thickness. Thinner inner retina was associated with alcohol intake (most significant for GCIPL: –0.46 μm for daily or almost daily intake compared with special occasion only or never [95% confidence interval (CI), 0.61–0.30]; P = 1.1×10–8), greater social deprivation (most significant for GCIPL: –0.28 μm for most deprived quartile compared with least deprived quartile [95% CI, –0.42 to –0.14]; P = 6.6×10–5), lower educational attainment (most significant for mRNFL: –0.36 μm for less than O level compared with degree level [95% CI, –0.45 to 0.26]; P = 2.3×10–14), and nonwhite ethnicity (most significant for mRNFL comparing blacks with whites: –1.65 μm [95% CI, –1.86 to –1.43]; P = 2.4×10–50). Corneal-compensated intraocular pressure was associated most significantly with GCIPL (–0.04 μm/mmHg [95% CI, –0.05 to –0.03]; P = 4.0×10–10) and was not associated significantly with mRNFL (0.00 μm/mmHg [95% CI, –0.01 to 0.01]; P = 0.77). The variables examined explained a greater proportion of the variance of GCIPL (11%) than GCC (6%) or mRNFL (7%). Conclusions: The novel associations we identified may be important to consider when using inner retinal parameters as a diagnostic tool. Associations generally were strongest with GCIPL, particularly for IOP. This suggests that GCIPL may be the superior inner retinal biomarker for macular pathophysiologic processes and especially for glaucoma.
UR - http://www.scopus.com/inward/record.url?scp=85072997299&partnerID=8YFLogxK
U2 - 10.1016/j.ophtha.2019.08.015
DO - 10.1016/j.ophtha.2019.08.015
M3 - Article
C2 - 31585827
AN - SCOPUS:85072997299
SN - 0161-6420
VL - 127
SP - 62
EP - 71
JO - Ophthalmology
JF - Ophthalmology
IS - 1
ER -