Complement Factor H: Using Atomic Resolution Structure to Illuminate Disease Mechanisms

Paul N. Barlow, Gregory S. Hageman, Susan M. Lea

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Complement Factor H has recently come to the fore with variant forms implicated in a range of serious disease states. This review aims to bring together recent data concerning the structure and biological activity of this molecule to highlight the way in which a molecular understanding of function may open novel therapeutic possibilities. In particular we examine the evidence for and against the hypothesis that sequence variations in factor H may predispose to disease if they perturb its ability to recognise and respond appropriately to polyanionic carbohydrates on host surfaces that require protection From complement-mediated damage.

Original languageEnglish
Title of host publicationCURRENT TOPICS IN COMPLEMENT II
EditorsJD Lambris
Place of PublicationBERLIN
PublisherSpringer-Verlag GmbH
Pages117-142
Number of pages26
ISBN (Print)978-0-387-78951-4
DOIs
Publication statusPublished - 2008
Event4th Aegean Workshop on Complement Associated Diseases, Animal Models and Therapeutics - Porto Heli
Duration: 10 Jun 200717 Jun 2007

Conference

Conference4th Aegean Workshop on Complement Associated Diseases, Animal Models and Therapeutics
CityPorto Heli
Period10/06/0717/06/07

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