Complete genome sequence and lytic phase transcription profile of a Coccolithovirus

William H Wilson, Declan C Schroeder, Michael J Allen, Matthew T G Holden, Julian Parkhill, Bart G Barrell, Carol Churcher, Nancy Hamlin, Karen Mungall, Halina Norbertczak, Michael A Quail, Claire Price, Ester Rabbinowitsch, Danielle Walker, Marie Craigon, Douglas Roy, Peter Ghazal

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi. Among the 472 predicted genes of the 407,339-base pair genome are a variety of unexpected genes, most notably those involved in biosynthesis of ceramide, a sphingolipid known to induce apoptosis. Uniquely for algal viruses, it also contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery. Microarray transcriptomic analysis reveals that 65% of the predicted virus-encoded genes are expressed during lytic infection of E. huxleyi.
Original languageEnglish
Pages (from-to)1090-2
Number of pages3
Issue number5737
Publication statusPublished - 2005

Keywords / Materials (for Non-textual outputs)

  • Apoptosis
  • Base Composition
  • Ceramides
  • Computational Biology
  • DNA, Viral
  • DNA-Directed RNA Polymerases
  • Eukaryota
  • Gene Expression
  • Gene Expression Profiling
  • Genes, Viral
  • Genome, Viral
  • Oligonucleotide Array Sequence Analysis
  • Peptide Hydrolases
  • Phycodnaviridae
  • Promoter Regions, Genetic
  • Protein Subunits
  • Sequence Analysis, DNA
  • Sphingolipids
  • Transcription, Genetic
  • Virus Replication


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