Complete sequencing of the Fugu WAGR region from WT1 to PAX6: dramatic compaction and conservation of synteny with human chromosome 11p13

C Miles, G Elgar, E Coles, D J Kleinjan, V van Heyningen, N Hastie

Research output: Contribution to journalArticlepeer-review

Abstract

The pufferfish Fugu rubripes has a genome approximately 7.5 times smaller than that of mammals but with a similar number of genes. Although conserved synteny has been demonstrated between pufferfish and mammals across some regions of the genome, there is some controversy as to what extent Fugu will be a useful model for the human genome, e.g., [Gilley, J., Armes, N. & Fried, M. (1997) Nature (London) 385, 305-306]. We report extensive conservation of synteny between a 1.5-Mb region of human chromosome 11 and
Original languageEnglish
Pages (from-to)13068-72
Number of pages5
JournalProceedings of the National Academy of Sciences
Volume95
Issue number22
DOIs
Publication statusPublished - 27 Oct 1998

Keywords

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11
  • Cosmids
  • DNA-Binding Proteins
  • Eye Proteins
  • Fishes
  • Genes, Wilms Tumor
  • Homeodomain Proteins
  • Humans
  • Mammals
  • Mice
  • Molecular Sequence Data
  • Paired Box Transcription Factors
  • Repressor Proteins
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Transcription Factors
  • WT1 Proteins
  • Xenopus

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