Complex genetic diseases: controversy over the Croesus code

A F Wright, N D Hastie

Research output: Contribution to journalArticlepeer-review


The polarization of views on how best to exploit new information from the Human Genome Project for medicine reflects our ignorance of the genetic architecture underlying common diseases: are susceptibility alleles common or rare, neutral or deleterious, few or many? Single-nucleotide polymorphism (SNP) technology is almost in place to dissect such diseases and to create a personalized medicine, but success is critically dependent on the biology and "Nature to be commanded must be obeyed" (Francis Bacon, 1620, Novum Organum).
Original languageEnglish
Pages (from-to)COMMENT2007
JournalGenome Biology
Issue number8
Publication statusPublished - 2001


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