Complex genetic diseases: controversy over the Croesus code

A F Wright; N D Hastie

doi:10.1186/gb-2001-2-8-comment2007

Complex genetic diseases: controversy over the Croesus code

A F Wright, N D Hastie

Research output: Contribution to journal › Article › peer-review

Abstract

The polarization of views on how best to exploit new information from the Human Genome Project for medicine reflects our ignorance of the genetic architecture underlying common diseases: are susceptibility alleles common or rare, neutral or deleterious, few or many? Single-nucleotide polymorphism (SNP) technology is almost in place to dissect such diseases and to create a personalized medicine, but success is critically dependent on the biology and "Nature to be commanded must be obeyed" (Francis Bacon, 1620, Novum Organum).

Original language	English
Pages (from-to)	COMMENT2007
Journal	Genome Biology
Volume	2
Issue number	8
DOIs	https://doi.org/10.1186/gb-2001-2-8-comment2007
Publication status	Published - 2001

Access to Document

10.1186/gb-2001-2-8-comment2007

Complex genetic diseases: controversy over the Croesus code
The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2001/2/8/comment/2007
Final published version, 177 KB

http://genomebiology.com/2001/2/8/comment/2007

Cite this

@article{bee271080527459a8b7c2c59fa35c349,

title = "Complex genetic diseases: controversy over the Croesus code",

abstract = "The polarization of views on how best to exploit new information from the Human Genome Project for medicine reflects our ignorance of the genetic architecture underlying common diseases: are susceptibility alleles common or rare, neutral or deleterious, few or many? Single-nucleotide polymorphism (SNP) technology is almost in place to dissect such diseases and to create a personalized medicine, but success is critically dependent on the biology and {"}Nature to be commanded must be obeyed{"} (Francis Bacon, 1620, Novum Organum).",

author = "Wright, {A F} and Hastie, {N D}",

year = "2001",

doi = "10.1186/gb-2001-2-8-comment2007",

language = "English",

volume = "2",

pages = "COMMENT2007",

journal = "Genome Biology",

issn = "1465-6906",

publisher = "BioMed Central",

number = "8",

}

TY - JOUR

T1 - Complex genetic diseases

T2 - controversy over the Croesus code

AU - Wright, A F

AU - Hastie, N D

PY - 2001

Y1 - 2001

N2 - The polarization of views on how best to exploit new information from the Human Genome Project for medicine reflects our ignorance of the genetic architecture underlying common diseases: are susceptibility alleles common or rare, neutral or deleterious, few or many? Single-nucleotide polymorphism (SNP) technology is almost in place to dissect such diseases and to create a personalized medicine, but success is critically dependent on the biology and "Nature to be commanded must be obeyed" (Francis Bacon, 1620, Novum Organum).

AB - The polarization of views on how best to exploit new information from the Human Genome Project for medicine reflects our ignorance of the genetic architecture underlying common diseases: are susceptibility alleles common or rare, neutral or deleterious, few or many? Single-nucleotide polymorphism (SNP) technology is almost in place to dissect such diseases and to create a personalized medicine, but success is critically dependent on the biology and "Nature to be commanded must be obeyed" (Francis Bacon, 1620, Novum Organum).

U2 - 10.1186/gb-2001-2-8-comment2007

DO - 10.1186/gb-2001-2-8-comment2007

M3 - Article

C2 - 11532206

SN - 1465-6906

VL - 2

SP - COMMENT2007

JO - Genome Biology

JF - Genome Biology

IS - 8

ER -

Complex genetic diseases: controversy over the Croesus code

Abstract

Access to Document

Fingerprint

Cite this