Complex genetic diseases: controversy over the Croesus code

A F Wright, N D Hastie

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The polarization of views on how best to exploit new information from the Human Genome Project for medicine reflects our ignorance of the genetic architecture underlying common diseases: are susceptibility alleles common or rare, neutral or deleterious, few or many? Single-nucleotide polymorphism (SNP) technology is almost in place to dissect such diseases and to create a personalized medicine, but success is critically dependent on the biology and "Nature to be commanded must be obeyed" (Francis Bacon, 1620, Novum Organum).
Original languageEnglish
Pages (from-to)COMMENT2007
JournalGenome Biology
Issue number8
Publication statusPublished - 2001


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