Projects per year
probes that bind multivalently to the entire length of the pathogen genomic DNA, such that a given probe binds to multiple sites along the target DNA. Our results suggest that multivalent targeting of long pieces of genomic DNA can allow highly sensitive and selective binding of the target DNA, even if competing DNA in the sample also contains binding sites for the same probe sequences. Our results are robust to mild fragmentation of the bacterial genome. Our conclusions may also be relevant for DNA detection in other fields, such as
disease diagnostics more broadly, environmental management and
FingerprintDive into the research topics of 'Computational design of probes to detect bacterial genomes by multivalent binding'. Together they form a unique fingerprint.
1/06/16 → 31/05/22
5/12/16 → 3/06/18
THREEDCELLPHYSICS: The physics of three dimensional chromosome and protein organisation within the cell
1/07/15 → 30/06/20