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Abstract / Description of output
One day prior to mass emergence of haematopoietic stem cells (HSCs) in the foetal liver at E12.5, the embryo contains only a few definitive HSCs. It is thought that the burst of HSC activity in the foetal liver is underpinned by rapid maturation of immature embryonic precursors of definitive HSCs, termed pre-HSCs. However, because pre-HSCs are not detectable by direct transplantations into adult irradiated recipients, the size and growth of this population, which represents the embryonic rudiment of the adult haematopoietic system, remains uncertain. Using a novel quantitative assay, we demonstrate that from E9.5 the pre-HSC pool undergoes dramatic growth in the aorta-gonad-mesonephros region and by E11.5 reaches the size that matches the number of definitive HSCs in the E12.5 foetal liver. Thus, this study provides for the first time a quantitative basis for our understanding of how the large population of definitive HSCs emerges in the foetal liver.
Original language | English |
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Pages (from-to) | 1284-1289 |
Number of pages | 6 |
Journal | Development |
Volume | 143 |
Issue number | 8 |
Early online date | 19 Apr 2016 |
DOIs | |
Publication status | Published - 19 Apr 2016 |
Keywords / Materials (for Non-textual outputs)
- AGM region
- HSC
- embryo
- pre-HSC
- mouse
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Dive into the research topics of 'Concealed expansion of immature precursors underpins acute burst of adult HSC activity in foetal liver'. Together they form a unique fingerprint.Projects
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Profiles
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Alexander Medvinsky
- School of Biological Sciences - Professor of Haematopoietic Stem Cell Biology
- Centre for Regenerative Medicine
- Edinburgh Haematopoiesis Network
Person: Academic: Research Active