Concept of the Munich/Augsburg Consortium Precision in Mental Health for the German Center of Mental Health

Peter Falkai; Nikolaos Koutsouleris; Katja Bertsch; Mirko Bialas; Elisabeth Binder; Markus Bühner; Alena Buyx; Na Cai; Silvia Cappello; Thomas Ehring; Jochen Gensichen; Johannes Hamann; Alkomiet Hasan; Peter Henningsen; Stefan Leucht; Karl Heinz Möhrmann; Elisabeth Nagelstutz; Frank Padberg; Annette Peters; Lea Pfäffel; Daniela Reich-erkelenz; Valentin Riedl; Daniel Rueckert; Andrea Schmitt; Gerd Schulte-körne; Elfriede Scheuring; Thomas G. Schulze; Rudolf Starzengruber; Susanne Stier; Fabian J. Theis; Juliane Winkelmann; Wolfgang Wurst; Josef Priller

doi:10.3389/fpsyt.2022.815718

Concept of the Munich/Augsburg Consortium Precision in Mental Health for the German Center of Mental Health

Peter Falkai, Nikolaos Koutsouleris, Katja Bertsch, Mirko Bialas, Elisabeth Binder, Markus Bühner, Alena Buyx, Na Cai, Silvia Cappello, Thomas Ehring, Jochen Gensichen, Johannes Hamann, Alkomiet Hasan, Peter Henningsen, Stefan Leucht, Karl Heinz Möhrmann, Elisabeth Nagelstutz, Frank Padberg, Annette Peters, Lea PfäffelDaniela Reich-erkelenz, Valentin Riedl, Daniel Rueckert, Andrea Schmitt, Gerd Schulte-körne, Elfriede Scheuring, Thomas G. Schulze, Rudolf Starzengruber, Susanne Stier, Fabian J. Theis, Juliane Winkelmann, Wolfgang Wurst, Josef Priller

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Frontiers in psychiatry
Volume	13
Early online date	4 Mar 2022
DOIs	https://doi.org/10.3389/fpsyt.2022.815718
Publication status	E-pub ahead of print - 4 Mar 2022

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10.3389/fpsyt.2022.815718

fpsyt-13-815718Final published version, 2.75 MBLicence: Creative Commons: Attribution (CC-BY)

https://www.frontiersin.org/articles/10.3389/fpsyt.2022.815718/full

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Falkai, P., Koutsouleris, N., Bertsch, K., Bialas, M., Binder, E., Bühner, M., Buyx, A., Cai, N., Cappello, S., Ehring, T., Gensichen, J., Hamann, J., Hasan, A., Henningsen, P., Leucht, S., Möhrmann, K. H., Nagelstutz, E., Padberg, F., Peters, A., ... Priller, J. (2022). Concept of the Munich/Augsburg Consortium Precision in Mental Health for the German Center of Mental Health. Frontiers in psychiatry, 13. https://doi.org/10.3389/fpsyt.2022.815718

@article{93897df8bf894d63be281c2d1e457cc8,

title = "Concept of the Munich/Augsburg Consortium Precision in Mental Health for the German Center of Mental Health",

author = "Peter Falkai and Nikolaos Koutsouleris and Katja Bertsch and Mirko Bialas and Elisabeth Binder and Markus B{\"u}hner and Alena Buyx and Na Cai and Silvia Cappello and Thomas Ehring and Jochen Gensichen and Johannes Hamann and Alkomiet Hasan and Peter Henningsen and Stefan Leucht and M{\"o}hrmann, {Karl Heinz} and Elisabeth Nagelstutz and Frank Padberg and Annette Peters and Lea Pf{\"a}ffel and Daniela Reich-erkelenz and Valentin Riedl and Daniel Rueckert and Andrea Schmitt and Gerd Schulte-k{\"o}rne and Elfriede Scheuring and Schulze, {Thomas G.} and Rudolf Starzengruber and Susanne Stier and Theis, {Fabian J.} and Juliane Winkelmann and Wolfgang Wurst and Josef Priller",

note = "Funding Information: This work was funded by the BMBF (DZPG PriMe 01EE2104). Funding Information: PriMe{\textquoteright}s translational mindset evolved through an array of national and international research consortia, centers of excellence, several graduate schools, a clear commitment to all aspects of evidence-based psychiatry, and a broad array of implementation approaches. PriMe members broadened the scope of these approaches from the classical “bench-to-bedside” paradigm to concepts of forward and reverse translation and “bench-to-individualized guideline” strategies. These structures not only permit a seamless translation of novel preclinical approaches to clinical care but also enable a reverse, “guideline-to-bench” translation. PriMe fully supports translational research in the DZPG with infrastructures that cover the entire translational chain. These infrastructures include outstanding platforms for the identification of risk factors (multi-omics technologies), the production and analysis of predictive human cellular and humanized animal models, drug discovery, highly specialized imaging tools, centralized biobanks, comprehensive patient cohorts, and an extensive network of clinical trial centers led by the Munich Study Center (MSZ). PriMe{\textquoteright}s specific contributions to DZPG research hubs include the central biorepository and datasets of the German National Cohort study (NAKO Gesundheitsstudie), the open-access German Mouse Clinic (GMC), the outstanding neuroimmunology hub (e.g., SyNergy Excellence cluster), the Leibniz Supercomputing Center (LRZ), strong artificial intelligence (AI)ML analysis platforms, NTBS facilities, comprehensive clinical trial and patient-recruitment infrastructures, and excellence in EBM via a Cochrane Review Group. Built in 2001, the GMC was the first platform worldwide () for systematic phenotyping and has advanced to a well-established and unique center for state-of-the-art mouse phenotyping. The GMC is an open-access phenotyping platform characterizing mouse models for human diseases in multiple body systems and physiological pathways in a variety of therapeutic areas. Its collaboration with more than 170 groups has resulted in more than 200 highly cited publications on neurodevelopmental and disorder-related phenotypes, advances in modeling abnormal neurodegenerative and aging patterns [with the German Center for Neurodegenerative Diseases (DZNE)], and diabetes models (with the German Center for Diabetes Research [DZD]). Founded in 1962, the LRZ is the IT service provider for PriMe partners and serves as a hub for other research organizations in Bavaria. LRZ is located in the Munich Metropolitan Area and is one of the three national members of the Gauss Center for Supercomputing, the High-Performance Computing Center Stuttgart (HLRS), and the J{\"u}lich Supercomputing Center. Helmholtz AI has established a network of method specialists (AI consultants) for short- and mid-term collaborations. The Helmholtz AI computing resources are available for all collaborative projects on identifying biomarkers and patient groups at risk for chronicity. The TUM Institute for AI and Informatics in Medicine ( AIIM@TUM ) is leading DIFUTURE, one of the four consortia funded by the BMBF, during the development and networking phase of the Medical Informatics Initiative. Its infrastructure and AI expertise will support the advanced analysis of preclinical and clinical data in a secure, federated, and privacy-preserving manner. Publisher Copyright: Copyright {\textcopyright} 2022 Falkai, Koutsouleris, Bertsch, Bialas, Binder, B{\"u}hner, Buyx, Cai, Cappello, Ehring, Gensichen, Hamann, Hasan, Henningsen, Leucht, M{\"o}hrmann, Nagelstutz, Padberg, Peters, Pf{\"a}ffel, Reich-Erkelenz, Riedl, Rueckert, Schmitt, Schulte-K{\"o}rne, Scheuring, Schulze, Starzengruber, Stier, Theis, Winkelmann, Wurst and Priller.",

year = "2022",

month = mar,

day = "4",

doi = "10.3389/fpsyt.2022.815718",

language = "English",

volume = "13",

journal = "Frontiers in psychiatry",

issn = "1664-0640",

publisher = "Frontiers Media S.A.",

}

Falkai, P, Koutsouleris, N, Bertsch, K, Bialas, M, Binder, E, Bühner, M, Buyx, A, Cai, N, Cappello, S, Ehring, T, Gensichen, J, Hamann, J, Hasan, A, Henningsen, P, Leucht, S, Möhrmann, KH, Nagelstutz, E, Padberg, F, Peters, A, Pfäffel, L, Reich-erkelenz, D, Riedl, V, Rueckert, D, Schmitt, A, Schulte-körne, G, Scheuring, E, Schulze, TG, Starzengruber, R, Stier, S, Theis, FJ, Winkelmann, J, Wurst, W & Priller, J 2022, 'Concept of the Munich/Augsburg Consortium Precision in Mental Health for the German Center of Mental Health', Frontiers in psychiatry, vol. 13. https://doi.org/10.3389/fpsyt.2022.815718

TY - JOUR

T1 - Concept of the Munich/Augsburg Consortium Precision in Mental Health for the German Center of Mental Health

AU - Falkai, Peter

AU - Koutsouleris, Nikolaos

AU - Bertsch, Katja

AU - Bialas, Mirko

AU - Binder, Elisabeth

AU - Bühner, Markus

AU - Buyx, Alena

AU - Cai, Na

AU - Cappello, Silvia

AU - Ehring, Thomas

AU - Gensichen, Jochen

AU - Hamann, Johannes

AU - Hasan, Alkomiet

AU - Henningsen, Peter

AU - Leucht, Stefan

AU - Möhrmann, Karl Heinz

AU - Nagelstutz, Elisabeth

AU - Padberg, Frank

AU - Peters, Annette

AU - Pfäffel, Lea

AU - Reich-erkelenz, Daniela

AU - Riedl, Valentin

AU - Rueckert, Daniel

AU - Schmitt, Andrea

AU - Schulte-körne, Gerd

AU - Scheuring, Elfriede

AU - Schulze, Thomas G.

AU - Starzengruber, Rudolf

AU - Stier, Susanne

AU - Theis, Fabian J.

AU - Winkelmann, Juliane

AU - Wurst, Wolfgang

AU - Priller, Josef

N1 - Funding Information: This work was funded by the BMBF (DZPG PriMe 01EE2104). Funding Information: PriMe’s translational mindset evolved through an array of national and international research consortia, centers of excellence, several graduate schools, a clear commitment to all aspects of evidence-based psychiatry, and a broad array of implementation approaches. PriMe members broadened the scope of these approaches from the classical “bench-to-bedside” paradigm to concepts of forward and reverse translation and “bench-to-individualized guideline” strategies. These structures not only permit a seamless translation of novel preclinical approaches to clinical care but also enable a reverse, “guideline-to-bench” translation. PriMe fully supports translational research in the DZPG with infrastructures that cover the entire translational chain. These infrastructures include outstanding platforms for the identification of risk factors (multi-omics technologies), the production and analysis of predictive human cellular and humanized animal models, drug discovery, highly specialized imaging tools, centralized biobanks, comprehensive patient cohorts, and an extensive network of clinical trial centers led by the Munich Study Center (MSZ). PriMe’s specific contributions to DZPG research hubs include the central biorepository and datasets of the German National Cohort study (NAKO Gesundheitsstudie), the open-access German Mouse Clinic (GMC), the outstanding neuroimmunology hub (e.g., SyNergy Excellence cluster), the Leibniz Supercomputing Center (LRZ), strong artificial intelligence (AI)ML analysis platforms, NTBS facilities, comprehensive clinical trial and patient-recruitment infrastructures, and excellence in EBM via a Cochrane Review Group. Built in 2001, the GMC was the first platform worldwide () for systematic phenotyping and has advanced to a well-established and unique center for state-of-the-art mouse phenotyping. The GMC is an open-access phenotyping platform characterizing mouse models for human diseases in multiple body systems and physiological pathways in a variety of therapeutic areas. Its collaboration with more than 170 groups has resulted in more than 200 highly cited publications on neurodevelopmental and disorder-related phenotypes, advances in modeling abnormal neurodegenerative and aging patterns [with the German Center for Neurodegenerative Diseases (DZNE)], and diabetes models (with the German Center for Diabetes Research [DZD]). Founded in 1962, the LRZ is the IT service provider for PriMe partners and serves as a hub for other research organizations in Bavaria. LRZ is located in the Munich Metropolitan Area and is one of the three national members of the Gauss Center for Supercomputing, the High-Performance Computing Center Stuttgart (HLRS), and the Jülich Supercomputing Center. Helmholtz AI has established a network of method specialists (AI consultants) for short- and mid-term collaborations. The Helmholtz AI computing resources are available for all collaborative projects on identifying biomarkers and patient groups at risk for chronicity. The TUM Institute for AI and Informatics in Medicine ( AIIM@TUM ) is leading DIFUTURE, one of the four consortia funded by the BMBF, during the development and networking phase of the Medical Informatics Initiative. Its infrastructure and AI expertise will support the advanced analysis of preclinical and clinical data in a secure, federated, and privacy-preserving manner. Publisher Copyright: Copyright © 2022 Falkai, Koutsouleris, Bertsch, Bialas, Binder, Bühner, Buyx, Cai, Cappello, Ehring, Gensichen, Hamann, Hasan, Henningsen, Leucht, Möhrmann, Nagelstutz, Padberg, Peters, Pfäffel, Reich-Erkelenz, Riedl, Rueckert, Schmitt, Schulte-Körne, Scheuring, Schulze, Starzengruber, Stier, Theis, Winkelmann, Wurst and Priller.

PY - 2022/3/4

Y1 - 2022/3/4

U2 - 10.3389/fpsyt.2022.815718

DO - 10.3389/fpsyt.2022.815718

M3 - Article

SN - 1664-0640

VL - 13

JO - Frontiers in psychiatry

JF - Frontiers in psychiatry

ER -