Concurrent white and gray matter degeneration of disease-specific networks in early-stage Alzheimer's disease and behavioral variant frontotemporal dementia

Rebecca M E Steketee, Rozanna Meijboom, Marius de Groot, Esther E Bron, Wiro J. Niessen, Aad van der Lugt, John C van Swieten, Marion Smits

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigates regional coherence between white matter (WM) microstructure and gray matter (GM) volume and perfusion measures in Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) using a correlational approach. WM-GM coherence, compared with controls, was stronger between cingulum WM and frontotemporal GM in AD, and temporoparietal GM in bvFTD. In addition, in AD compared with controls, coherence was stronger between inferior fronto-occipital fasciculus WM microstructure and occipital GM perfusion. In this first study assessing regional WM-GM coherence in AD and bvFTD, we show that WM microstructure and GM volume and perfusion measures are coherent, particularly in regions implicated in AD and bvFTD pathology. This indicates concurrent degeneration in disease-specific networks. Our methodology allows for the detection of incipient abnormalities that go undetected in conventional between-group analyses.

Original languageEnglish
Pages (from-to)119-28
Number of pages10
JournalNeurobiology of Aging
Volume43
Early online date7 Apr 2016
DOIs
Publication statusPublished - Jul 2016

Keywords

  • Alzheimer Disease
  • Diffusion Magnetic Resonance Imaging
  • Frontotemporal Dementia
  • Gray Matter
  • Humans
  • Magnetic Resonance Angiography
  • Nerve Degeneration
  • White Matter

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