TY - JOUR
T1 - Condensin and cohesin complexity
T2 - The expanding repertoire of functions
AU - Wood, A.J.
AU - Severson, A.F.
AU - Meyer, B.J.
PY - 2010/6/1
Y1 - 2010/6/1
N2 - Condensin and cohesin complexes act in diverse nuclear processes in addition to their widely known roles in chromosome compaction and sister chromatid cohesion. Recent work has elucidated the contribution of condensin and cohesin to interphase genome organization, control of gene expression, metazoan development and meiosis. Despite these wide-ranging functions, several themes have come to light: both complexes establish higher-order chromosome structure by inhibiting or promoting interactions between distant genomic regions, both complexes influence the chromosomal association of other proteins, and both complexes achieve functional specialization by swapping homologous subunits. Emerging data are expanding the range of processes in which condensin and cohesin are known to participate and are enhancing our knowledge of how chromosome architecture is regulated to influence numerous cellular functions.
AB - Condensin and cohesin complexes act in diverse nuclear processes in addition to their widely known roles in chromosome compaction and sister chromatid cohesion. Recent work has elucidated the contribution of condensin and cohesin to interphase genome organization, control of gene expression, metazoan development and meiosis. Despite these wide-ranging functions, several themes have come to light: both complexes establish higher-order chromosome structure by inhibiting or promoting interactions between distant genomic regions, both complexes influence the chromosomal association of other proteins, and both complexes achieve functional specialization by swapping homologous subunits. Emerging data are expanding the range of processes in which condensin and cohesin are known to participate and are enhancing our knowledge of how chromosome architecture is regulated to influence numerous cellular functions.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-77952563068&partnerID=8YFLogxK
U2 - 10.1038/nrg2794
DO - 10.1038/nrg2794
M3 - Article
AN - SCOPUS:77952563068
SN - 1471-0056
VL - 11
SP - 391
EP - 404
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 6
ER -